INT19963

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 5
Speculated 4
Reported most in Body
Documents 118
Total Number 122
Disease Relevance 42.11
Pain Relevance 15.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
cartilage 6
TMJ 6
fibroblasts 4
chondrocytes 3
osteoblast 3
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 430 100.00 Very High Very High Very High
fibrosis 280 100.00 Very High Very High Very High
chemokine 79 100.00 Very High Very High Very High
reflex sympathetic dystrophy 44 100.00 Very High Very High Very High
Snapping jaw 62 99.96 Very High Very High Very High
Endocannabinoid 120 99.64 Very High Very High Very High
metalloproteinase 131 99.52 Very High Very High Very High
diclofenac 72 99.38 Very High Very High Very High
Chronic pancreatitis 214 99.24 Very High Very High Very High
Osteoarthritis 880 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fibrosis 460 100.00 Very High Very High Very High
Osteoporosis 287 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 84 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 16 99.98 Very High Very High Very High
Primary Sclerosing Cholangitis 310 99.96 Very High Very High Very High
Temporomandibular Joint Syndrome 62 99.96 Very High Very High Very High
Osteoarthritis 958 99.50 Very High Very High Very High
Stress 1181 99.44 Very High Very High Very High
Pancreatitis 224 99.24 Very High Very High Very High
Coronary Artery Disease 10 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All genes were found to be regulated in the same direction with either method, however two genes (COL1A1 and COL3A1) did not meet the FC>1.2 criteria (?
Neg (not) Gene_expression (meet) of COL1A1
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0 Pain Relevance 0
Lastly, using fluorescent staining, we examined fibronectin and collagen I expression in TMJ discs.
Spec (examined) Gene_expression (expression) of collagen I in TMJ
2) Confidence 0.58 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The levels of fibronectin and collagen I in the TMJ disc and synovial fluid may be influenced by the stage of disease.
Gene_expression (levels) of collagen I in TMJ
3) Confidence 0.58 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
Fibronectin or collagen I expression in human TMJ synovial aspirates and disc tissue may indicate the proteins' involvement in closed lock.
Gene_expression (expression) of collagen I in TMJ associated with snapping jaw
4) Confidence 0.58 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.80 Pain Relevance 0.57
We compared the fluorescent staining and light microscopy results of both proteins within each disc to confirm fibronectin and collagen I expression.
Gene_expression (expression) of collagen I
5) Confidence 0.58 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
The urinary COL1A1 peptide that is most differentially expressed in active SJIA (TableĀ 8) extends beyond the C terminus of a closely related peptide found in normal plasma, suggesting it may be generated by inhibition of normal protease activity during SJIA.
Gene_expression (expressed) of COL1A1 in plasma
6) Confidence 0.56 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.22 Pain Relevance 0.07
Moreover, linkage disequilibrium with other bone-metabolism-related genes on chromosome 12 (i.e. collagen type 1 and retinoic acid receptor genes) cannot be excluded.
Gene_expression (excluded) of collagen type 1
7) Confidence 0.55 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical staining of HUCM constructs after 4 weeks revealed a strong presence of collagen I and minute amounts of collagen II, whereas TMJ constructs revealed little collagen I and no collagen II.
Gene_expression (presence) of collagen I in TMJ associated with snapping jaw
8) Confidence 0.54 Published 2007 Journal Tissue Eng. Section Abstract Doc Link 17518722 Disease Relevance 0.85 Pain Relevance 0.85
In contrast, COL1 expression was significantly suppressed in physiological conditions throughout culture.
Gene_expression (expression) of COL1
9) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.20 Pain Relevance 0.10
Chondrocyte dedifferentiation might also play a role in the pathogenesis of OA, as the ability of aging chondrocytes to produce and repair the extracellular matrix is compromised [37] and as COL1 is shown to be present in chondrocyte clusters in fibrillated areas of late-stage OA cartilage while it is absent in healthy cartilage [38].
Neg (absent) Gene_expression (present) of COL1 in cartilage associated with aging and osteoarthritis
10) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.38 Pain Relevance 0.10
The same observation holds for COL1 expression in the early passages, but not for COL1 expression in the later passages.
Gene_expression (expression) of COL1
11) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.16 Pain Relevance 0
The same observation holds for COL1 expression in the early passages, but not for COL1 expression in the later passages.
Gene_expression (expression) of COL1
12) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.21 Pain Relevance 0.03
In the present article we report that physiological tonicity (380 mOsm) during isolation and monolayer expansion can suppress chondrocyte dedifferentiation and that expression of the extracelluar matrix components collagen type I and collagen type II as well as aggrecan is NFAT5 dependent.
Gene_expression (expression) of collagen type I in chondrocyte
13) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.46 Pain Relevance 0.15
As in OA HACs, hypertonicity also downregulated COL1 expression with increasing passage number in NHACs: the COL2/COL1 ratios increased during expansion (Figure 3d), from 6.8-fold in P0 cells to 355-fold in expanded P3 cells.
Gene_expression (expression) of COL1 associated with osteoarthritis
14) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.16 Pain Relevance 0.08
In contrast, physiological tonicity significantly decreased COL1 protein expression (Figure 2f), from twofold in P0 cells to 13-fold in P1 cells.
Gene_expression (expression) of COL1
15) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.13 Pain Relevance 0.07
As fibrocartilaginous collagen type I and hyaline collagen type II expression are differentially regulated in chondrocytes [34], analyzing the collagen type II/type I expression ratios is informative of chondrogenic potential [51].
Gene_expression (expression) of collagen type I in chondrocytes
16) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.29 Pain Relevance 0.08
There was no considerable difference in detection of either fibronectin or collagen I in TMJ synovial aspirates from patients with advanced disc pathology compared with controls.
Gene_expression (detection) of collagen I in TMJ
17) Confidence 0.50 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
RESULTS: Disc specimens with advanced morphologic pathology showed significant labeling for fibronectin in 3 of 3 cases and for collagen I in 4 of 4 cases.
Gene_expression (significant) of collagen I
18) Confidence 0.50 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
Analysis of the collagen I and fibronectin of temporomandibular joint synovial fluid and discs.
Gene_expression (Analysis) of collagen I in synovial fluid associated with snapping jaw
19) Confidence 0.50 Published 2009 Journal J. Oral Maxillofac. Surg. Section Title Doc Link 19070755 Disease Relevance 0.75 Pain Relevance 0.54
CRPS type I according to Veldman is diagnosed when four of the following five symptoms are present and occur or increase with activity:
Gene_expression (diagnosed) of CRPS type I associated with reflex sympathetic dystrophy
20) Confidence 0.49 Published 2010 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2835870 Disease Relevance 0.69 Pain Relevance 0.65

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