INT199640

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.97
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 7 77.76 Quite High
Spinal cord 5 71.96 Quite High
Inflammation 1 68.00 Quite High
Peripheral nervous system 1 66.68 Quite High
Paracetamol 2 16.96 Low Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 168 100.00 Very High Very High Very High
Disease 46 99.90 Very High Very High Very High
Friedreich Ataxia 53 99.84 Very High Very High Very High
Neurodegenerative Disease 5 99.12 Very High Very High Very High
Metabolic Disorder 3 95.20 Very High Very High Very High
Cerebellar Ataxia 49 90.76 High High
Marinesco Sjogren Syndrome 6 85.28 High High
Telangiectasia 14 83.28 Quite High
Dna Damage 17 82.80 Quite High
Rare Diseases 2 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, biomarkers are vital to the development of therapeutic approaches, and our study points to possible drug interventions, like modulating the ubiquitin-proteasome system or upregulating molecular chaperone activity, which may be as useful for FRDA as they are in other neurodegenerative diseases.
Positive_regulation (upregulating) of Positive_regulation (useful) of FRDA associated with ataxia and neurodegenerative disease
1) Confidence 0.41 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.02 Pain Relevance 0.03
These diseases are due to mutations in specific genes, some of which have been identified, such as frataxin in Friedreich ataxia, ?
Positive_regulation (due) of Positive_regulation (mutations) of frataxin associated with friedreich ataxia and disease
2) Confidence 0.28 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1664553 Disease Relevance 1.95 Pain Relevance 0.11

General Comments

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