INT199642

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.60
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 14 77.76 Quite High
Spinal cord 10 71.68 Quite High
Peripheral nervous system 2 66.40 Quite High
Inflammation 1 65.64 Quite High
Paracetamol 2 16.96 Low Low
Sicca syndrome 12 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 260 100.00 Very High Very High Very High
Friedreich Ataxia 106 99.84 Very High Very High Very High
Disease 77 99.76 Very High Very High Very High
Neurodegenerative Disease 6 99.12 Very High Very High Very High
Targeted Disruption 13 95.84 Very High Very High Very High
Metabolic Disorder 6 94.92 High High
Cerebellar Ataxia 97 90.48 High High
Marinesco Sjogren Syndrome 12 85.00 Quite High
Embryonic Lethality 2 83.52 Quite High
Telangiectasia 28 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, biomarkers are vital to the development of therapeutic approaches, and our study points to possible drug interventions, like modulating the ubiquitin-proteasome system or upregulating molecular chaperone activity, which may be as useful for FRDA as they are in other neurodegenerative diseases.
Positive_regulation (useful) of FRDA associated with ataxia and neurodegenerative disease
1) Confidence 0.41 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.00 Pain Relevance 0.03
Proteins containing ISC are sensitive to free oxygen radicals and may be affected by accumulation of mitochondrial iron in frataxin deficiency states.
Positive_regulation (accumulation) of frataxin
2) Confidence 0.28 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.65 Pain Relevance 0
These diseases are due to mutations in specific genes, some of which have been identified, such as frataxin in Friedreich ataxia, ?
Positive_regulation (mutations) of frataxin associated with friedreich ataxia and disease
3) Confidence 0.28 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1664553 Disease Relevance 1.95 Pain Relevance 0.11

General Comments

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