INT199643

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Anatomy Link Frequency
adipocyte 1
respiratory 1
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 92.44 High High
imagery 14 5.00 Very Low Very Low Very Low
Sicca syndrome 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Friedreich Ataxia 106 100.00 Very High Very High Very High
Disease 62 99.60 Very High Very High Very High
Death 2 94.64 High High
Targeted Disruption 10 81.92 Quite High
Stress 8 76.96 Quite High
Iron Overload 4 24.24 Low Low
Coronary Heart Disease 8 23.64 Low Low
Sprains And Strains 4 19.68 Low Low
Ataxia 184 15.68 Low Low
Embryonic Lethality 2 5.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further experiments showing direct participation of frataxin in the respiratory chain (by interaction with protein of complex II) suggested FRDA as an oxidative phosphorylation (OXPHOS) disease [141,142].
Phosphorylation (phosphorylation) of FRDA in respiratory associated with friedreich ataxia and disease
1) Confidence 0.40 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.92 Pain Relevance 0.03
Another hypothesis (based on experiments in mammalian adipocyte cells that overexpressed frataxin) suggested frataxin as an activator of mitochondrial energy conversion and oxidative phosphorylation [127].
Phosphorylation (phosphorylation) of frataxin in adipocyte
2) Confidence 0.35 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.12 Pain Relevance 0.05

General Comments

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