INT199646

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 4.78
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 86.64 High High
Action potential 2 81.20 Quite High
Spinal cord 5 35.04 Quite Low
Paracetamol 16 5.00 Very Low Very Low Very Low
Taxol 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Friedreich Ataxia 53 100.00 Very High Very High Very High
Disease 151 99.96 Very High Very High Very High
Ataxia 700 96.28 Very High Very High Very High
Impaired Glucose Tolerance 2 94.88 High High
Diabetes Mellitus 10 93.96 High High
Deafness 4 93.04 High High
Optic Atrophy 1 92.64 High High
Neurodegenerative Disease 33 92.28 High High
Ocular Toxicity (including Many Sub-types) 9 92.04 High High
Foot Deformities 3 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this disease, transcription of frataxin, a mitochondrial protein involved in iron homeostasis, is impaired, resulting in a significant reduction in mRNA and protein levels.
Transcription (transcription) of frataxin associated with disease
1) Confidence 0.67 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2799513 Disease Relevance 0.71 Pain Relevance 0
Additionally, frataxin mRNA levels correlated with age of onset of disease and displayed unique sets of gene alterations involved in immune response, oxidative phosphorylation, and protein synthesis.
Transcription (levels) of frataxin associated with disease
2) Confidence 0.67 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2799513 Disease Relevance 0.83 Pain Relevance 0
To determine relative frataxin mRNA levels, Real-time PCR was carried out using the ABI Prism 7900HT sequence detection system.
Spec (determine) Transcription (levels) of frataxin
3) Confidence 0.67 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.08 Pain Relevance 0
Analyses of clinical features and gene expression patterns correlate with age of onset and frataxin mRNA levels, as well as altered protein synthesis with frataxin levels, ICARS score, and age of diagnosis.
Transcription (levels) of frataxin
4) Confidence 0.67 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.96 Pain Relevance 0.04
0.305 for the relationship of frataxin mRNA levels to age of onset (Figure 4C), and p?
Transcription (relationship) of frataxin
5) Confidence 0.64 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.09 Pain Relevance 0
0.344) for the relationship of frataxin mRNA levels with the short GAA repeat length (Figure S2).
Transcription (levels) of frataxin
6) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.14 Pain Relevance 0
Correlations of frataxin mRNA levels to all available clinical data for each child were also performed by univariate linear modeling.
Transcription (levels) of frataxin
7) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0 Pain Relevance 0
We further sought to find correlations of frataxin mRNA levels to all available clinical data for each child, including DNA lesions and disease duration, but only found an association, by univariate linear modeling, with age of onset and number of short GAA repeats.
Transcription (levels) of frataxin associated with disease
8) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.10 Pain Relevance 0
The isolation of the FRDA gene and description of the GAA trinucleotide expansion as the main mutation have allowed to define the clinical picture and the phenotypic variability based on biological markers [78-80] (Table 2).
Transcription (description) of FRDA associated with friedreich ataxia
9) Confidence 0.44 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.87 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox