INT199649

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 32
Disease Relevance 20.90
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Anatomy Link Frequency
liver 2
M cell 2
embryo 1
cerebral cortex 1
pancreas 1
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 55 99.84 Very High Very High Very High
cerebral cortex 11 96.36 Very High Very High Very High
Bioavailability 11 93.80 High High
Inflammation 21 84.68 Quite High
Action potential 22 75.76 Quite High
Paracetamol 42 33.76 Quite Low
imagery 77 5.00 Very Low Very Low Very Low
Sicca syndrome 66 5.00 Very Low Very Low Very Low
peripheral neuropathy 22 5.00 Very Low Very Low Very Low
medulla 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 2608 100.00 Very High Very High Very High
Friedreich Ataxia 583 100.00 Very High Very High Very High
Lifespan 64 99.08 Very High Very High Very High
Targeted Disruption 118 98.88 Very High Very High Very High
Malignant Neoplastic Disease 53 98.08 Very High Very High Very High
Cancer 126 97.84 Very High Very High Very High
Sprains And Strains 106 97.80 Very High Very High Very High
Disease 656 96.88 Very High Very High Very High
Coronary Heart Disease 65 96.32 Very High Very High Very High
Stress 401 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analyses of clinical features and gene expression patterns correlate with age of onset and frataxin mRNA levels, as well as altered protein synthesis with frataxin levels, ICARS score, and age of diagnosis.
Gene_expression (synthesis) of frataxin
1) Confidence 0.72 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.96 Pain Relevance 0.04
We, therefore, decided to obtain relative gene expression levels of frataxin by TaqMan Real-time PCR [70].
Gene_expression (expression) of frataxin
2) Confidence 0.72 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.10 Pain Relevance 0
Conversely, overexpression of human frataxin in murine cells increases antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, and reduces the incidence of ROS-induced malignant transformation [10].
Gene_expression (overexpression) of frataxin associated with malignant neoplastic disease
3) Confidence 0.72 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.02 Pain Relevance 0
When they disrupted expression of frataxin in mouse hepatocytes, lifespan was not only reduced, but the livers had increased oxidative stress and mitochondrial dysfunction.
Gene_expression (expression) of frataxin in livers associated with parkinson's disease, stress and lifespan
4) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.23 Pain Relevance 0
The levels of frataxin obtained are relative to the average ?
Gene_expression (levels) of frataxin
5) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.06 Pain Relevance 0
Tan et al. [25] reported 48 significant frataxin-dependent differentially expressed genes in at least two of the human cell types.
Gene_expression (expressed) of frataxin
6) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.66 Pain Relevance 0
Supervised analysis to find genes associated with case versus control or low frataxin expression versus high expression was performed using Significance Analysis of Microarrays (SAM) after pooling the raw data [29].
Gene_expression (expression) of frataxin
7) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0 Pain Relevance 0
A univariate linear model was constructed to test this association, and no genes in this set were found to be significantly associated with frataxin levels.
Gene_expression (levels) of frataxin
8) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.08 Pain Relevance 0
0.05, in order to assess the global impact of FRDA on gene expression.
Gene_expression (expression) of FRDA associated with ataxia
9) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.46 Pain Relevance 0
More work is needed to understand the causes of the pathobiology associated with the progression of FRDA.
Gene_expression (progression) of FRDA associated with ataxia
10) Confidence 0.63 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.24 Pain Relevance 0
The same study further demonstrates how low levels of frataxin in a RAD52 double-strand break repair deficient yeast strain lead to rapid G2/M cell cycle arrest, which is consistent with nuclear damage.
Gene_expression (levels) of frataxin in M cell associated with sprains and strains
11) Confidence 0.56 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.55 Pain Relevance 0
Moreover, evidence consistent with nuclear DNA (nDNA) damage is demonstrated by decreasing the levels of frataxin in a RAD52 (854976) double-strand break repair deficient yeast strain, which results in rapid G2/M cell cycle arrest [16].
Gene_expression (levels) of frataxin in M cell associated with sprains and strains
12) Confidence 0.56 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.68 Pain Relevance 0
2.5 was selected to separate these two modes, resulting in six patients considered “high-frataxin expressers” and 21 patients designated “low-frataxin expressers” (Figure 4A and Figure S1).
Gene_expression (expressers) of frataxin
13) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.13 Pain Relevance 0
The level of injury in the cells of these patients is not only exacerbated by the loss of antioxidative defense, but also by the downregulation of oxidative phosphorylation and the shutdown of protein synthesis and translation, as was observed in the gene expression analysis of patients with lower levels of frataxin as compared to patients with higher levels.
Gene_expression (levels) of frataxin associated with injury
14) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.84 Pain Relevance 0
2.5 was selected to separate these two modes, resulting in six patients considered “high-frataxin expressers” and 21 patients designated “low-frataxin expressers” (Figure 4A and Figure S1).
Gene_expression (expressers) of frataxin
15) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.14 Pain Relevance 0
Top scoring categories and pathways included protein biosynthesis, oxidative phosphorylation, ubiquinone biosynthesis, nucleotide excision repair, and protein ubiquitination, all of which were downregulated in those patients expressing lower levels of frataxin (Figure 4B).
Gene_expression (expressing) of frataxin
16) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.10 Pain Relevance 0
The level of injury in the cells of these patients is not only exacerbated by the loss of antioxidative defense, but also by the downregulation of oxidative phosphorylation and the shutdown of protein synthesis and translation, as was observed in the gene expression analysis of patients with lower levels of frataxin as compared to patients with higher levels.
Gene_expression (expression) of frataxin associated with injury
17) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.86 Pain Relevance 0
Since the bioinformatics analyses in this study were applied to SAM-derived data based on pooling the raw data from all 28 children (Materials and Methods), we tested the hypothesis that a discrete set of genes would be differentially expressed in patients with the lowest levels of frataxin.
Gene_expression (expressed) of frataxin
18) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.18 Pain Relevance 0
In conclusion, our results yield insight into the nature and progression of FRDA, as well as possible therapeutic approaches.
Gene_expression (progression) of FRDA associated with ataxia
19) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2799513 Disease Relevance 0.88 Pain Relevance 0
0.05, for FRDA children and FRDA adults, respectively; data not shown) may explain the malignant transformation potential of frataxin-deficient cells, both in vitro and in vivo [10],[48],[52].
Gene_expression (adults) of FRDA associated with malignant neoplastic disease and ataxia
20) Confidence 0.55 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.98 Pain Relevance 0

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