INT19965

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 14.49
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
PRP 1
coronary artery 1
endothelial cells 1
PSCs 1
spine 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 55 100.00 Very High Very High Very High
cytokine 109 99.72 Very High Very High Very High
Inflammation 164 98.60 Very High Very High Very High
Osteoarthritis 29 97.88 Very High Very High Very High
Angina 12 95.52 Very High Very High Very High
rheumatoid arthritis 28 95.00 High High
spondylitis 6 94.48 High High
Spinal cord 4 92.80 High High
fibrosis 65 89.92 High High
Chronic pancreatitis 103 88.96 High High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 84 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 14 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 231 99.62 Very High Very High Very High
Coronary Artery Disease 8 99.58 Very High Very High Very High
Dyskinesias 6 99.56 Very High Very High Very High
INFLAMMATION 186 98.60 Very High Very High Very High
Uterine Fibroids 120 98.04 Very High Very High Very High
Osteoarthritis 34 97.88 Very High Very High Very High
Cv General 3 Under Development 13 95.52 Very High Very High Very High
Myocardial Infarction 6 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The psychological context (anxio-depressive state) showed a (sub-significant) tendency to increase the risk of CRPS I (relative risk=2.6).
Positive_regulation (increase) of CRPS I
1) Confidence 0.45 Published 2009 Journal Foot Ankle Surg Section Body Doc Link 19840748 Disease Relevance 0.06 Pain Relevance 0
1, and COL1A1 mRNAs were all increased (Fig. 2B).
Positive_regulation (increased) of COL1A1
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.31 Pain Relevance 0
It is marked by reduced bone density (at lumbar spine and femoral neck), increased bone turnover (with increased urinary C-telopeptide cross-linked collagen type 1), but without any significant change in phosphocalcic blood parameters.
Positive_regulation (increased) of collagen type 1 in spine
3) Confidence 0.39 Published 2006 Journal Rev Med Interne Section Abstract Doc Link 16274875 Disease Relevance 1.53 Pain Relevance 0.51
As in OA HACs, hypertonicity also downregulated COL1 expression with increasing passage number in NHACs: the COL2/COL1 ratios increased during expansion (Figure 3d), from 6.8-fold in P0 cells to 355-fold in expanded P3 cells.
Positive_regulation (increased) of COL1 associated with osteoarthritis
4) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.16 Pain Relevance 0.08
The mRNA expression was increased for collagen genes COL1A1 (2·72 ± 0·55-fold; P < 0·05) and COL4A1 (2·95 ± 0·37-fold; P < 0·05) in leiomyoma cells as compared to myometrial cells prior to treatment (Fig. 3).
Positive_regulation (increased) of COL1A1 associated with uterine fibroids
5) Confidence 0.32 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.79 Pain Relevance 0
Levels of serum alkaline phosphatase and urinary collagen type I N-telopeptide were elevated at baseline and decreased continuously during the first 3 yr of therapy.
Positive_regulation (elevated) of collagen type I N-telopeptide
6) Confidence 0.25 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557424 Disease Relevance 0.47 Pain Relevance 0.08
Lyophilized PP and PRP resulted in increased COL1A1:COL3A1 ratio, increased COMP, and decreased MMP-13 expression.
Positive_regulation (increased) of COL1A1 in PRP
7) Confidence 0.21 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.10
Treatment with bortezomib caused a significant increase in bone-specific alkaline phosphatase and pro-collagen type I N-terminal propeptide, a novel bone formation marker.
Positive_regulation (increase) of collagen type I
8) Confidence 0.18 Published 2010 Journal European Journal of Haematology Section Abstract Doc Link PMC2970902 Disease Relevance 0.45 Pain Relevance 0
When comparing the diagnostic value of skin temperature asymmetries in CRPS I, sensitivity was only 32% under resting conditions, but increased up to 76% during controlled alteration of sympathetic activity.
Positive_regulation (increased) of CRPS I in skin associated with complex regional pain syndromes
9) Confidence 0.14 Published 2002 Journal Pain Section Abstract Doc Link 12098613 Disease Relevance 0.47 Pain Relevance 0.12
In vitro, the authors found that gene expression levels of T/L-associated genes by cells seeded in silk-collagen scaffolds compared to silk alone were substantially higher, and showed collagen type I elevated by 250% and decorin elevated by over 500%.
Positive_regulation (elevated) of collagen type I
10) Confidence 0.11 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0 Pain Relevance 0
Cell-associated fibrillar collagen types I and III and fibronectin increased after addition of PAP to PSCs.
Positive_regulation (increased) of collagen types I and III in PSCs
11) Confidence 0.09 Published 2009 Journal Pancreatology Section Body Doc Link 19077460 Disease Relevance 0.07 Pain Relevance 0
1, the most potent pro-fibrogenic cytokine, was able to up-regulate collagen type I in HSC/MFs by eliciting H2O2-dependent signalling involving the binding of p35 C/EBP?
Positive_regulation (up-regulate) of collagen type I associated with cytokine
12) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.20 Pain Relevance 0.11
1 rose to nearly 100%, but also an increase of collagen type I could be determined.
Positive_regulation (increase) of collagen type I
13) Confidence 0.05 Published 2007 Journal The Open Biomedical Engineering Journal Section Body Doc Link PMC2701085 Disease Relevance 0.21 Pain Relevance 0
Moreover, this site specific variance in ECM deposition can be due to the following reasons: 1) The packed immune clusters are actually forming in expanded perivascular spaces as hinted by the presence of central CD31 positive endothelial cells; 2) In vitro, the matrix degradation enzyme MMP-1 was increased together with an increase in ECM proteins collagen1 and fibronectin; 3) High amounts of TNFalpha exert cytotoxic effects on PSC [20] which is probably represented in vivo as a function of their density.
Positive_regulation (increase) of collagen1 in endothelial cells associated with primary sclerosing cholangitis
14) Confidence 0.05 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.60 Pain Relevance 0.03
TNFalpha induced an increase in collagen1 (p = 0.069) and an increase in fibronectin levels (p = 0.007).


Positive_regulation (increase) of collagen1
15) Confidence 0.05 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.71 Pain Relevance 0.08
Hou and colleagues found that cathepsin K has a potent aggrecan-degrading activity, whereby the aggrecan cleavage products increase the collagenolytic effects of this protease on collagen type I and type II.
Positive_regulation (increase) of collagen type I in cleavage
16) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.58 Pain Relevance 0.17
Collagen types I and III, fibronectin, matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs) and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) were demonstrated on protein and mRNA level.
Positive_regulation (inducing) of Collagen types I and III
17) Confidence 0.04 Published 2009 Journal Pancreatology Section Body Doc Link 19077460 Disease Relevance 0.08 Pain Relevance 0
This assumption is underlined by increased ECM protein secretion in TNFalpha- and LPS-treated PSC and a concomitant increase in collagen1 and fibronectin as well as in pro-inflammatory cytokines IL-6 and MCP-1 following coculture of PSC with PBMC.
Positive_regulation (increase) of collagen1 associated with inflammation, primary sclerosing cholangitis and cytokine
18) Confidence 0.03 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.29 Pain Relevance 0.54
Finally, HNE seems much more selective in its activity towards HSC/MFs, since it causes the up-regulation of only a limited number of genes, including those encoding collagen type I, TGF?
Positive_regulation (causes) of collagen type I
19) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.17 Pain Relevance 0
Strong indications exist for differences in effects for subgroups of patients with warm or cold CRPS I: for warm CRPS I, DMSO-treatment appears more favorable, while for cold CRPS I, NAC-treatment appears to be more effective.
Spec (appears) Positive_regulation (effective) of CRPS I associated with complex regional pain syndromes
20) Confidence 0.03 Published 2003 Journal Pain Section Abstract Doc Link 12670672 Disease Relevance 0.80 Pain Relevance 0.13

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