INT199653

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc) plasma membrane (Tfrc)
Anatomy Link Frequency
plasma 1
Tfrc (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 1 16.80 Low Low
Paracetamol 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 92 98.06 Very High Very High Very High
Iron Overload 2 94.92 High High
Friedreich Ataxia 53 86.72 High High
Stress 4 81.20 Quite High
Disease 31 75.80 Quite High
Apoptosis 72 71.04 Quite High
Pathologic Constriction 1 68.72 Quite High
Targeted Disruption 101 62.96 Quite High
Death 1 56.60 Quite High
Sprains And Strains 14 50.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The basis for ER specificity was not clarified, but the specificity implies that CAPER may not enhance ER function through association with NCoA6(ASC-2), which interacts with and enhances activation of NRs including RARs, RXRs, TR and GR.
Positive_regulation (activation) of TR
1) Confidence 0.13 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Although different laboratories have reported differences in the extent of activation by various NRs in NCoA6-/- MEFs, the overall conclusion is that NCoA6 functions as a coactivator for RXR, RAR, TR and PPAR.
Positive_regulation (coactivator) of TR
2) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.35 Pain Relevance 0
Expression of CoAA enhances activation by a number of transcription factors including NF-kB, CREB, AP-1, TR, ER and GR.
Positive_regulation (activation) of TR
3) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CAPER did not appear to enhance activation of other NRs such as RARs, RXRs, TR and GR.
Positive_regulation (activation) of TR
4) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
However, Friedriech's ataxia patients have normal plasma levels of iron and ferritin [144], although the plasma level of the transferrin receptor is increased [145].
Positive_regulation (increased) of transferrin receptor in plasma associated with ataxia
5) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.22 Pain Relevance 0

General Comments

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