INT199654

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.95
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Anatomy Link Frequency
adipocyte 2
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 93.80 High High
imagery 14 5.00 Very Low Very Low Very Low
Sicca syndrome 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Friedreich Ataxia 106 99.66 Very High Very High Very High
Targeted Disruption 16 98.88 Very High Very High Very High
Ataxia 336 95.76 Very High Very High Very High
Syndrome 66 95.20 Very High Very High Very High
Malignant Neoplastic Disease 6 94.56 High High
Stress 42 93.84 High High
Hypersensitivity 2 84.36 Quite High
Disease 92 81.32 Quite High
Coronary Heart Disease 10 62.40 Quite High
Dna Damage 34 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, overexpression of human frataxin in murine cells increases antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, and reduces the incidence of ROS-induced malignant transformation [10].
Positive_regulation (overexpression) of Gene_expression (overexpression) of frataxin associated with malignant neoplastic disease
1) Confidence 0.64 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.02 Pain Relevance 0
Conversely, overexpression of human frataxin in murine cells increases antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, and reduces the incidence of ROS-induced malignant transformation [10].
Positive_regulation (increases) of Gene_expression (overexpression) of frataxin associated with malignant neoplastic disease
2) Confidence 0.47 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.07 Pain Relevance 0
The use of EPO in the treatment of Friedreich ataxia is based on the increased in vitro frataxin expression in response to EPO [150].


Positive_regulation (increased) of Gene_expression (expression) of frataxin associated with friedreich ataxia
3) Confidence 0.39 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.81 Pain Relevance 0
Another hypothesis (based on experiments in mammalian adipocyte cells that overexpressed frataxin) suggested frataxin as an activator of mitochondrial energy conversion and oxidative phosphorylation [127].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of frataxin in adipocyte
4) Confidence 0.26 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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