INT199655

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.34
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fxn) transport (Fxn) mitochondrion (Fxn)
oxidoreductase activity (Fxn) mitochondrion organization (Fxn) enzyme binding (Fxn)
Anatomy Link Frequency
livers 2
M cell 2
Fxn (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 68.72 Quite High
Spinal cord 5 65.08 Quite High
imagery 7 5.00 Very Low Very Low Very Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Taxol 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Friedreich Ataxia 53 100.00 Very High Very High Very High
Lifespan 8 99.08 Very High Very High Very High
Targeted Disruption 14 98.88 Very High Very High Very High
Malignant Neoplastic Disease 7 98.80 Very High Very High Very High
Sprains And Strains 14 97.44 Very High Very High Very High
Stress 55 96.28 Very High Very High Very High
Parkinson's Disease 9 95.84 Very High Very High Very High
Ataxia 320 94.16 High High
Cancer 18 85.64 High High
Hypersensitivity 3 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When they disrupted expression of frataxin in mouse hepatocytes, lifespan was not only reduced, but the livers had increased oxidative stress and mitochondrial dysfunction.
Negative_regulation (disrupted) of Gene_expression (expression) of frataxin in livers associated with parkinson's disease, stress and lifespan
1) Confidence 0.47 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.23 Pain Relevance 0
Moreover, evidence consistent with nuclear DNA (nDNA) damage is demonstrated by decreasing the levels of frataxin in a RAD52 (854976) double-strand break repair deficient yeast strain, which results in rapid G2/M cell cycle arrest [16].
Negative_regulation (decreasing) of Gene_expression (levels) of frataxin in M cell associated with sprains and strains
2) Confidence 0.40 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.68 Pain Relevance 0
Conversely, overexpression of human frataxin in murine cells increases antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, and reduces the incidence of ROS-induced malignant transformation [10].
Negative_regulation (reduces) of Gene_expression (overexpression) of frataxin associated with malignant neoplastic disease
3) Confidence 0.40 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 1.08 Pain Relevance 0
The expanded GAA repeat results in inhibition of the FRDA gene expression.
Negative_regulation (inhibition) of Gene_expression (expression) of FRDA associated with friedreich ataxia
4) Confidence 0.38 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.35 Pain Relevance 0.07

General Comments

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