INT19966

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 21.88
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C9orf3) cytoplasm (C9orf3)
Anatomy Link Frequency
fat 3
plasma 2
molar 2
blood 1
coronary artery 1
C9orf3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 64 99.04 Very High Very High Very High
Angina 30 96.96 Very High Very High Very High
Restless leg syndrome 6 95.28 Very High Very High Very High
Chronic pancreatitis 8 93.32 High High
Inflammatory marker 2 91.80 High High
Pain 2 80.16 Quite High
headache 2 76.08 Quite High
nud 1 73.12 Quite High
cINOD 2 71.16 Quite High
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 118 100.00 Very High Very High Very High
Hypercholesterolemia 2 100.00 Very High Very High Very High
Coronary Artery Disease 24 99.58 Very High Very High Very High
Chronic Renal Failure 12 99.28 Very High Very High Very High
Hyperlipidemia 13 99.08 Very High Very High Very High
Rheumatoid Arthritis 64 99.04 Very High Very High Very High
Myocardial Infarction 12 98.76 Very High Very High Very High
Congenital Anomalies 3 98.42 Very High Very High Very High
Diabetes Mellitus 8 97.68 Very High Very High Very High
Increased Venous Pressure Under Development 18 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, one year of therapy with DMARDs resulted in a significant increase in the serum levels of total cholesterol, HDL-cholesterol and Apo A-I compared with the respective baseline values (Table 1).
Positive_regulation (increase) of Apo associated with disorder of lipid metabolism
1) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.37 Pain Relevance 0.29
In these patients, the molar ratio of Apo A-I to Apo A-II and HDL-associated Apo A-I levels were decreased, and free Apo A-I levels were increased.
Positive_regulation (increased) of Apo in molar associated with disorder of lipid metabolism
2) Confidence 0.67 Published 1990 Journal Circulation Section Abstract Doc Link 2111741 Disease Relevance 1.64 Pain Relevance 0.48
Cilostazol also increased plasma high density lipoprotein cholesterol (HDL-C) (10%) and apolipoprotein (apo) A1 (5.7%) significantly (P<0.001 and P<0.01, respectively).
Positive_regulation (increased) of apo in plasma associated with disorder of lipid metabolism
3) Confidence 0.67 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9848888 Disease Relevance 0.93 Pain Relevance 0.42
The results were as follows: in BYHWD group the serum level of lipoperoxide (LPO), apolipoprotein (apo) B100, LPO/SOD (superoxide dismutase) and apo B100/apo A1 were lowered remarkably, the serum of SOD and apo A1 were elevated significantly (P < 0.01) comparing with the control group.
Positive_regulation (elevated) of apo associated with disorder of lipid metabolism
4) Confidence 0.67 Published 1995 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 7647542 Disease Relevance 0.64 Pain Relevance 0.18
The most frequent lipid abnormalities found were: hypertriglyceridemia; hypercholesterolemia; decreased HDL levels; elevated cholesterol/HDL and apoproteins (Apo B/A-1); and elevated lipoprotein [Lp(a)] levels.
Positive_regulation (elevated) of Apo associated with congenital anomalies, hyperlipidemia, disorder of lipid metabolism and hypercholesterolemia
5) Confidence 0.49 Published 1993 Journal Perit Dial Int Section Abstract Doc Link 8399630 Disease Relevance 1.47 Pain Relevance 0.09
Both drugs significantly reduced apolipoprotein (apo) B and lipoparticles (Lp) E:B, and increased apo A-I but had divergent effects on LpA-I (increased with fluvastatin and reduced with gemfibrozil; p < 0.05).
Positive_regulation (increased) of apo associated with disorder of lipid metabolism
6) Confidence 0.49 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017467 Disease Relevance 1.17 Pain Relevance 0
Even though reduced HDL cholesterol was found in RA patients, the HDL/LDL ratio was normal and the apo A-I/apo B ratio was increased, suggesting that these patients are not at increased risk for atherosclerosis.
Positive_regulation (increased) of apo associated with rheumatoid arthritis, increased venous pressure under development and disorder of lipid metabolism
7) Confidence 0.49 Published 1985 Journal Br. J. Rheumatol. Section Abstract Doc Link 3860273 Disease Relevance 1.02 Pain Relevance 0.22
Even though reduced HDL cholesterol was found in RA patients, the HDL/LDL ratio was normal and the apo A-I/apo B ratio was increased, suggesting that these patients are not at increased risk for atherosclerosis.
Positive_regulation (increased) of apo associated with rheumatoid arthritis, increased venous pressure under development and disorder of lipid metabolism
8) Confidence 0.49 Published 1985 Journal Br. J. Rheumatol. Section Abstract Doc Link 3860273 Disease Relevance 1.02 Pain Relevance 0.22
In these patients, the molar ratio of Apo A-I to Apo A-II and HDL-associated Apo A-I levels were decreased, and free Apo A-I levels were increased.
Positive_regulation (ratio) of Apo in molar associated with disorder of lipid metabolism
9) Confidence 0.49 Published 1990 Journal Circulation Section Abstract Doc Link 2111741 Disease Relevance 1.65 Pain Relevance 0.50
To investigate the prostaglandin I2 (PGI2) half-life regulated by high density lipoprotein (HDL) in patients with coronary artery disease (CAD), we determined the stability of PGI2 and serum apolipoprotein A-I (Apo A-I) and apolipoprotein A-II (Apo A-II) levels in four age-matched groups of patients: controls (n = 17), angina pectoris (n = 18), unstable angina pectoris (n = 17), myocardial infarction (n = 19) (acute phase, 3.6 +/- 1.7 hours from onset; subacute phase, 75 +/- 15 hours from onset in the same patients).
Spec (determined) Positive_regulation (stability) of Apo in coronary artery associated with angina, coronary artery disease, myocardial infarction and disorder of lipid metabolism
10) Confidence 0.49 Published 1990 Journal Circulation Section Abstract Doc Link 2111741 Disease Relevance 1.35 Pain Relevance 0.50
On the other hand, the apo A-IV levels were high in patients with chronic renal failure and in those with diabetes mellitus and proteinuria.
Positive_regulation (high) of apo associated with chronic renal failure, diabetes mellitus and proteinuria
11) Confidence 0.49 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3781171 Disease Relevance 1.37 Pain Relevance 0.16
Static leg exercise with loads exceeding 60 kg were associated with atherogenic changes of blood lipid transport system: elevation of levels of triglycerides, apoprotein B and apo B/A ratio both in healthy subjects and patients, and of total and low density lipoprotein cholesterol in patients.
Positive_regulation (elevation) of apo in blood
12) Confidence 0.45 Published 2003 Journal Kardiologiia Section Abstract Doc Link 12891270 Disease Relevance 0.35 Pain Relevance 0.09
LDL-unbound apo(a) molecules are elevated in patients with ESRD.
Positive_regulation (elevated) of apo associated with chronic renal failure
13) Confidence 0.45 Published 1997 Journal Clin. Genet. Section Abstract Doc Link 9520130 Disease Relevance 1.02 Pain Relevance 0
It was established that changes in the plasma lipid and apoprotein spectrum result in an increase of apo B, decrease of apo 1, increase of apo B/apo A1, decrease of high-density lipoprotein cholesterol (HDLCS) and a different dynamics of HDLCS/apo A1.
Positive_regulation (increase) of apo in plasma
14) Confidence 0.45 Published 1990 Journal Vrach Delo Section Abstract Doc Link 2339543 Disease Relevance 0.26 Pain Relevance 0.09
Decrease in VLDL triglyceride was associated with increase in apo C-II/C-III ratio in all the cases.
Positive_regulation (increase) of apo
15) Confidence 0.45 Published 1993 Journal Kidney Int. Section Abstract Doc Link 8301936 Disease Relevance 0.94 Pain Relevance 0.08
Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).
Positive_regulation (increased) of apo associated with disorder of lipid metabolism
16) Confidence 0.45 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.00 Pain Relevance 0.26
During a year, increased "atherogenic" changes in the spectrum of Lp, apo were revealed in patients with a more severe clinical course of the disease as compared to an "instability" period; when the disease proceeded favourably, a "positive" time-course of these parameters was observed.
Positive_regulation (increased) of apo associated with disease
17) Confidence 0.45 Published 1989 Journal Kardiologiia Section Abstract Doc Link 2615176 Disease Relevance 1.10 Pain Relevance 0.30
Oral fat ingestion resulted in an increase of apo A-IV levels which remained elevated even when the postprandial hypertriglyceridemia had disappeared.
Positive_regulation (increase) of apo in fat associated with hyperlipidemia
18) Confidence 0.45 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3781171 Disease Relevance 1.17 Pain Relevance 0.16
A transient increase in apo A-IV levels was observed after intravenous fat infusion but the level declined simultaneously with decreases in triglyceride levels.
Positive_regulation (increase) of apo in fat
19) Confidence 0.45 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3781171 Disease Relevance 1.17 Pain Relevance 0.16
Oral fat ingestion resulted in an increase of apo A-IV levels which remained elevated even when the postprandial hypertriglyceridemia had disappeared.
Positive_regulation (elevated) of apo in fat associated with hyperlipidemia
20) Confidence 0.45 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3781171 Disease Relevance 1.17 Pain Relevance 0.16

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