INT199661

Context Info Confidence 0.04 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.84 Pain Relevance 0

cytosol (TTPA) transport (TTPA) intracellular (TTPA) lipid metabolic process (TTPA) cytoplasm (TTPA)

TTPA (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 2 30.64 imagery 7 5.00 Sicca syndrome 6 5.00 Spinal cord 5 5.00 peripheral neuropathy 2 5.00 medulla 2 5.00 Bile 2 5.00 Action potential 2 5.00 cerebral cortex 1 5.00 midbrain 1 5.00

Disease Link Frequency Relevance Heat Vitamin Deficiency 1 100.00 Ataxia 92 99.72 Neurodegenerative Disease 1 97.00 Hypolipidemia 9 95.98 Advanced Or Metastatic Breast Cancer 20 95.44 Endometriosis (extended) 8 94.08 Cerebellar Ataxia 48 78.48 Marinesco Sjogren Syndrome 6 74.40 Friedreich Ataxia 53 71.04 Telangiectasia 14 68.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, none of these trials demonstrated statistically significant improvements in all three end points (ORR, TTP, and OS) for the aromatase inhibitor compared with tamoxifen.

Negative_regulation (inhibitor) of TTP

1) Confidence 0.04 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001219 Disease Relevance 0.34 Pain Relevance 0

Abetalipoproteinemia, which is associated with severe neurodegenerative complications, belongs to the potentially treatable or preventable conditions associated with vitamin E deficiency, similarly to ataxia with vitamin deficiency (AVED) due to mutations in the ?

Negative_regulation (deficiency) of AVED associated with ataxia, hypolipidemia, vitamin deficiency and neurodegenerative disease

2) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.51 Pain Relevance 0

General Comments

This test has worked.