INT19967

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 26.51
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C9orf3) cytoplasm (C9orf3)
Anatomy Link Frequency
Body 3
coronary artery 1
fat 1
CII 1
C9orf3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 99.90 Very High Very High Very High
Angina 57 99.68 Very High Very High Very High
rheumatoid arthritis 56 96.20 Very High Very High Very High
Chronic pancreatitis 8 94.20 High High
palliative 1 90.72 High High
Inflammatory marker 2 85.68 High High
carpal tunnel syndrome 1 84.60 Quite High
headache 3 77.28 Quite High
Pain 3 75.76 Quite High
nud 3 74.32 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 235 100.00 Very High Very High Very High
Alzheimer's Dementia 5 100.00 Very High Very High Very High
Hypercholesterolemia 2 100.00 Very High Very High Very High
INFLAMMATION 18 99.90 Very High Very High Very High
Cv General 3 Under Development 44 99.68 Very High Very High Very High
Angina 13 99.28 Very High Very High Very High
Coronary Artery Disease 208 99.24 Very High Very High Very High
Hyperlipidemia 15 99.24 Very High Very High Very High
Atherosclerosis 20 98.84 Very High Very High Very High
Obesity 31 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Gene_expression (levels) of Apo associated with rheumatoid arthritis and disorder of lipid metabolism
1) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.41 Pain Relevance 0.30
Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).
Gene_expression (produced) of apo associated with disorder of lipid metabolism
2) Confidence 0.75 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.03 Pain Relevance 0.26
ApoA: Apolipoprotein A; APOA1: Apolipoprotein A1 gene; APOA5: Apolipoprotein A5 gene; ApoB: Apolipoprotein B; APOC3: Apolipoprotein C3 gene; ASPs: Affected sibling pairs; BMI: Body mass index; CAD: Coronary Artery Disease; FCHL: Familial Combined Hyperlipidemia; HDL-c: High-Density Lipoprotein cholesterol; HTN: Hypertension; IBD: Identity By Descent; IBS: Identity By State.
Gene_expression (gene) of Apo in Body associated with inflammatory bowel disease, familial combined hyperlipidemia, coronary artery disease, hypertension, obesity and disorder of lipid metabolism
3) Confidence 0.65 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 1.97 Pain Relevance 0
ApoA: Apolipoprotein A; APOA1: Apolipoprotein A1 gene; APOA5: Apolipoprotein A5 gene; ApoB: Apolipoprotein B; APOC3: Apolipoprotein C3 gene; ASPs: Affected sibling pairs; BMI: Body mass index; CAD: Coronary Artery Disease; FCHL: Familial Combined Hyperlipidemia; HDL-c: High-Density Lipoprotein cholesterol; HTN: Hypertension; IBD: Identity By Descent; IBS: Identity By State.
Gene_expression (gene) of Apo in Body associated with inflammatory bowel disease, familial combined hyperlipidemia, coronary artery disease, hypertension, obesity and disorder of lipid metabolism
4) Confidence 0.65 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 2.00 Pain Relevance 0
ApoA: Apolipoprotein A; APOA1: Apolipoprotein A1 gene; APOA5: Apolipoprotein A5 gene; ApoB: Apolipoprotein B; APOC3: Apolipoprotein C3 gene; ASPs: Affected sibling pairs; BMI: Body mass index; CAD: Coronary Artery Disease; FCHL: Familial Combined Hyperlipidemia; HDL-c: High-Density Lipoprotein cholesterol; HTN: Hypertension; IBD: Identity By Descent; IBS: Identity By State.
Gene_expression (gene) of Apo in Body associated with inflammatory bowel disease, familial combined hyperlipidemia, coronary artery disease, hypertension, obesity and disorder of lipid metabolism
5) Confidence 0.65 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 1.90 Pain Relevance 0
This resulted in a better total cholesterol:HDL-c ratio (from 3.9 to 3.7) (although the difference was not statistically significant), and an improved Apo B:Apo A-I ratio, which decreased by 7.5% over time (P=0.008).
Gene_expression (ratio) of Apo
6) Confidence 0.65 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404933 Disease Relevance 0.26 Pain Relevance 0
Using an in vitro model of beta2-m-related amyloid fibril (fAbeta2-m) extension, we demonstrated that various amyloid-associated molecules, such as apolipoprotein (apo) E and proteoglycans, accelerate beta2-m amyloid fibril formation.
Gene_expression (various) of apo associated with alzheimer's dementia and disorder of lipid metabolism
7) Confidence 0.65 Published 2003 Journal Nephrology (Carlton) Section Abstract Doc Link 15012691 Disease Relevance 1.04 Pain Relevance 0.08
Serum C, TG, Lp(a), apo E, apo A-I, apo B, HDL-C and RLP-C were measured in 652 patients who underwent diagnostic coronary angiography.
Gene_expression (measured) of apo associated with disorder of lipid metabolism
8) Confidence 0.65 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9712343 Disease Relevance 0.85 Pain Relevance 0.08
In summary, it seems that LDL-unbound apo(a) levels do not contribute to the prediction of carotid atherosclerosis in hemodialysis patients.
Gene_expression (levels) of apo associated with atherosclerosis
9) Confidence 0.65 Published 1997 Journal Clin. Genet. Section Abstract Doc Link 9520130 Disease Relevance 0.95 Pain Relevance 0.09
The most frequent lipid abnormalities found were: hypertriglyceridemia; hypercholesterolemia; decreased HDL levels; elevated cholesterol/HDL and apoproteins (Apo B/A-1); and elevated lipoprotein [Lp(a)] levels.
Gene_expression (levels) of Apo associated with congenital anomalies, hyperlipidemia, disorder of lipid metabolism and hypercholesterolemia
10) Confidence 0.65 Published 1993 Journal Perit Dial Int Section Abstract Doc Link 8399630 Disease Relevance 1.47 Pain Relevance 0.09
Lipid and apolipoprotein (apo) levels in patients with variant angina were examined and compared with patients with coronary artery disease (CAD) and normal subjects (control).
Gene_expression (levels) of apo in coronary artery associated with angina, coronary artery disease and disorder of lipid metabolism
11) Confidence 0.65 Published 1989 Journal Am. J. Cardiol. Section Abstract Doc Link 2729130 Disease Relevance 1.06 Pain Relevance 0.35
Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).
Gene_expression (produced) of apo associated with disorder of lipid metabolism
12) Confidence 0.65 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.03 Pain Relevance 0.26
Apolipoprotein A-II (apo A-II) levels were significantly higher in the VSA group than in the C and CAD groups.
Gene_expression (higher) of apo associated with angina, coronary artery disease and disorder of lipid metabolism
13) Confidence 0.65 Published 1989 Journal Jpn. J. Med. Section Abstract Doc Link 2661890 Disease Relevance 2.44 Pain Relevance 0.87
Apolipoprotein A-II (apo A-II) levels were significantly higher in the VSA group than in the C and CAD groups.
Gene_expression (levels) of apo associated with angina, coronary artery disease and disorder of lipid metabolism
14) Confidence 0.65 Published 1989 Journal Jpn. J. Med. Section Abstract Doc Link 2661890 Disease Relevance 2.43 Pain Relevance 0.87
The main effect of the operation is to lower the LDL apolipoprotein (apo) B-100 production rate, but there is little effect on the fractional rate of clearance of this apolipoprotein.
Gene_expression (production) of apo associated with disorder of lipid metabolism
15) Confidence 0.58 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2643427 Disease Relevance 0.71 Pain Relevance 0.09
Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%).
Gene_expression (produced) of apo associated with disorder of lipid metabolism
16) Confidence 0.58 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 1.03 Pain Relevance 0.27
Levels of serum apo A-IV were decreased under conditions where decreased fat intake or malabsorption of nutrients might have been present, such as in patients with chronic pancreatitis, malabsorption syndrome, acute hepatitis in the early stage, obstructive jaundice and in postoperative patients on total parenteral nutrition.
Gene_expression (Levels) of apo in fat associated with malabsorption syndromes, chronic pancreatitis, obstructive jaundice and hepatitis
17) Confidence 0.58 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3781171 Disease Relevance 1.19 Pain Relevance 0.17
The plasma levels of TG, apo CII and RLP-C were highest in the VSA group, followed by the CAD group.
Gene_expression (levels) of apo in CII
18) Confidence 0.58 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.24 Pain Relevance 0
The correlation between the concentrations of inflammatory protein and apo A-IV suggest a link between chronic inflammation and apo A-IV synthesis or catabolism.
Gene_expression (synthesis) of apo associated with inflammation
19) Confidence 0.58 Published 2001 Journal Metab. Clin. Exp. Section Abstract Doc Link 11555832 Disease Relevance 1.54 Pain Relevance 0.29
Serum PGI2 half-life and total serum Apo A-I levels were lower in the CAD group than in the control group.
Gene_expression (levels) of Apo associated with coronary artery disease
20) Confidence 0.58 Published 1990 Journal Circulation Section Abstract Doc Link 2111741 Disease Relevance 1.58 Pain Relevance 0.52

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