INT199690

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2006
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.96
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (2610029G23Rik) cellular_component (2610029G23Rik) biological_process (2610029G23Rik)
Anatomy Link Frequency
liver 2
caudal vein 1
2610029G23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 15 74.88 Quite High
imagery 15 68.32 Quite High
ketamine 5 5.24 Low Low
Potency 15 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 620 99.56 Very High Very High Very High
Sprains And Strains 75 98.84 Very High Very High Very High
Cancer 5 94.72 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 92.08 High High
Infection 50 90.88 High High
Exsanguination 5 72.28 Quite High
Body Weight 15 51.68 Quite High
Death 10 25.00 Low Low
Increased Venous Pressure Under Development 5 25.00 Low Low
Chronic Disease 5 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the researchers showed that OPC-67683 had no effects on the liver enzymes that metabolize antiretrovirals, and, conversely, that the activity of OPC-67683 was not affected by liver enzymes.
Neg (not) Regulation (affected) of OPC-67683 in liver
1) Confidence 0.16 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1664607 Disease Relevance 0.88 Pain Relevance 0
Finally, the researchers showed that OPC-67683 had no effects on the liver enzymes that metabolize antiretrovirals, and, conversely, that the activity of OPC-67683 was not affected by liver enzymes.
Neg (not) Regulation (affected) of OPC-67683 in liver
2) Confidence 0.12 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1664607 Disease Relevance 0.91 Pain Relevance 0
The IC50 values of OPC-67683 for mycolic acid subclasses were lower than those of INH, and these results correlated well with the in vitro anti-tubercular activity of OPC-67683 and INH.
Regulation (values) of OPC-67683
3) Confidence 0.07 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.69 Pain Relevance 0
In order to examine the therapeutic efficacy of OPC-67683 and to determine the therapeutic dose range, an experimental mouse model of chronic TB was established by inoculating Institute of Cancer Research (ICR) mice with M. tuberculosis Kurono through the caudal vein and allowing the infection to develop for 28 d.
Spec (examine) Regulation (efficacy) of OPC-67683 in caudal vein associated with mycobacterial infection, cancer and infection
4) Confidence 0.07 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.72 Pain Relevance 0.07
In addition, the efficacy of OPC-67683 in combination with currently used anti-TB drugs RFP, INH, EB, and SM was examined in vitro using the checkerboard method.
Spec (examined) Regulation (efficacy) of OPC-67683 associated with mycobacterial infection
5) Confidence 0.07 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.75 Pain Relevance 0.03

General Comments

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