INT199693

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.58
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (2610029G23Rik) cellular_component (2610029G23Rik) biological_process (2610029G23Rik)
Anatomy Link Frequency
plasma 1
2610029G23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 24 91.88 High High
Potency 24 88.24 High High
imagery 24 70.36 Quite High
ketamine 8 67.28 Quite High
Bioavailability 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 120 99.20 Very High Very High Very High
Mycobacterial Infection 992 99.08 Very High Very High Very High
Bacterial Infection 8 50.68 Quite High
Infection 80 37.40 Quite Low
Exsanguination 8 34.88 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 176 33.72 Quite Low
Body Weight 24 5.00 Very Low Very Low Very Low
Death 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For OPC-67683, the plasma obtained was filtered through a 0.22-?
Gene_expression (obtained) of OPC-67683 in plasma
1) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.19 Pain Relevance 0.16
No metabolites, however, were observed after mixing OPC-67683 with an experimentally obtained OPC-67683-resistant M. bovis BCG Tokyo strain.
Gene_expression (mixing) of OPC-67683-resistant associated with sprains and strains
2) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.10 Pain Relevance 0.03
No metabolites, however, were observed after mixing OPC-67683 with an experimentally obtained OPC-67683-resistant M. bovis BCG Tokyo strain.
Gene_expression (mixing) of OPC-67683 associated with sprains and strains
3) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.10 Pain Relevance 0.03
After mixing OPC-67683 with M. bovis BCG Tokyo, we identified only one main metabolite, and this metabolite eluted faster than OPC-67683.
Gene_expression (mixing) of OPC-67683
4) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.19 Pain Relevance 0.04
The efficacy profiles of OPC-67683 were similarly excellent in both types of mice.


Gene_expression (profiles) of OPC-67683
5) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.14 Pain Relevance 0
OPC-67683, PA-824, and CGI-17341 were synthesized at Otsuka Pharmaceutical (http://www.otsuka.global.com); RFP, INH, EB, streptomycin (SM), and PZA were purchased from Sigma (http://www.sigmaaldrich.com).
Gene_expression (synthesized) of OPC-67683
6) Confidence 0.15 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.31 Pain Relevance 0
With OPC-67683, however, the main metabolite produced in the presence of M. tuberculosis was identified as a non-active desnitro-imidazooxazole.
Gene_expression (produced) of OPC-67683 associated with mycobacterial infection
7) Confidence 0.15 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.33 Pain Relevance 0.07
The doses of OPC-67683, RFP, INH, EB, SM, and PZA that could produce a CFU reduction of at least 95% in this experimental mouse model were 0.625, 3.5, 5, >160, 40, and 160 mg/kg, respectively.


Gene_expression (produce) of OPC-67683
8) Confidence 0.10 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.21 Pain Relevance 0

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