INT199697

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (2610029G23Rik) cellular_component (2610029G23Rik) biological_process (2610029G23Rik)
2610029G23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 9 99.32 Very High Very High Very High
anesthesia 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 372 98.92 Very High Very High Very High
Bacterial Infection 3 67.40 Quite High
Infection 30 51.12 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 66 50.44 Quite High
Sprains And Strains 45 7.28 Low Low
Body Weight 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Exsanguination 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed a mutation in the Rv3547 gene among the resistant organisms, indicating Rv3547 to be a key enzyme involved in activating OPC-67683, as it was for PA-824 (unpublished data).
Positive_regulation (activating) of OPC-67683
1) Confidence 0.18 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.34 Pain Relevance 0.07
This result suggests that Rv3547 possesses a reduction potency of the nitro residue and that an intermediate between OPC-67683 and the desnitro-imidazooxazole could be the active form.
Positive_regulation (intermediate) of OPC-67683 associated with potency
2) Confidence 0.13 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.30 Pain Relevance 0.05
We then further evaluated OPC-67683 to determine whether the compound could help address the unmet needs of TB treatment.


Positive_regulation (evaluated) of OPC-67683 associated with mycobacterial infection
3) Confidence 0.13 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1664607 Disease Relevance 0.56 Pain Relevance 0

General Comments

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