INT199723

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.31
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Anatomy Link Frequency
immune cells 1
CAR 1
hepatocyte 1
nucleus 1
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 89 98.44 Very High Very High Very High
aspirin 4 70.24 Quite High
Inflammation 63 69.16 Quite High
cINOD 16 62.04 Quite High
Inflammatory response 10 48.08 Quite Low
Bile 50 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 121 97.36 Very High Very High Very High
Hypersensitivity 22 94.08 High High
Autoimmune Disease 1 89.44 High High
Pressure And Volume Under Development 13 78.48 Quite High
Infection 9 69.68 Quite High
INFLAMMATION 78 69.16 Quite High
Inflammatory Bowel Disease 33 65.12 Quite High
Congenital Anomalies 2 55.24 Quite High
Disease 68 54.56 Quite High
Cancer 69 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic deletion of hepatocyte-specific RXR?
Localization (deletion) of RXR in hepatocyte
1) Confidence 0.59 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.21 Pain Relevance 0.34
Likewise, the I-box of the partner of RXR is equally vital to heterodimerization, such as VDR K382E (equivalent to human RXR?
Localization (partner) of RXR
2) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
resides upstream of RXR?
Localization (upstream) of RXR
3) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
They are activated by ligand binding; form heterodimers, usually with the retinoid X receptor (RXR); translocate to the nucleus; bind to a cis-acting XRE consisting of a direct repeat of two hexanucleotides, separated by one or two nucleotides, in the promoter region of the target gene; and enhance target gene expression [17].
Localization (translocate) of RXR in nucleus
4) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0
They identified differential spatial and temporal recruitment of PPARs and RXR to target sites during adipogenesis; in particular, at the onset of differentiation the DNA occupancy by RXR alone was detected.
Localization (recruitment) of RXR
5) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.14 Pain Relevance 0.06
Interestingly, immediately afterwards, many of these sites become occupied by RXR and PPAR?
Localization (occupied) of RXR
6) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.15 Pain Relevance 0.05
Similarly, action of vitamin A, so called retinol, is mediated over antigen presenting cells (APC) through specific intracellular receptors (RAR, RXR) [10,11], which are present in the immune cells.
Localization (present) of RXR in immune cells
7) Confidence 0.05 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.26 Pain Relevance 0
Transrepression occurs through sequestration of the coactivators CBP and SRC-1 by the PPAR/RXR heterodimers, preventing their utilization in other signaling pathways [62].
Localization (sequestration) of RXR
8) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.06 Pain Relevance 0
B and other nuclear receptors, since RXR is a common partner for many nuclear receptors including CAR, VDR, RAR, TR, LXR and PPARs [Xie and Tian, 2006].
Localization (receptors) of RXR in CAR
9) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.49 Pain Relevance 0.13

General Comments

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