INT199724

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 6.22
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Anatomy Link Frequency
immune cells 2
peripheral nervous system 2
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 173 100.00 Very High Very High Very High
Spinal cord 76 99.36 Very High Very High Very High
Peripheral nervous system 12 99.28 Very High Very High Very High
Arthritis 8 95.72 Very High Very High Very High
Multiple sclerosis 1 94.56 High High
cytokine 32 85.60 High High
aspirin 19 80.00 Quite High
Central nervous system 34 71.84 Quite High
antagonist 39 63.04 Quite High
alcohol 2 60.80 Quite High
Disease Link Frequency Relevance Heat
Infertility 1 99.98 Very High Very High Very High
Injury 53 99.68 Very High Very High Very High
Lung Cancer 12 98.84 Very High Very High Very High
Apoptosis 165 96.88 Very High Very High Very High
Asthma 7 96.32 Very High Very High Very High
Arthritis 8 95.72 Very High Very High Very High
Diabetes Mellitus 91 95.12 Very High Very High Very High
Multiple Sclerosis 3 94.56 High High
Obesity 215 93.04 High High
Breast Cancer 11 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonists of either RXR or PPAR, leading to the activation of
Positive_regulation (leading) of Gene_expression (agonists) of RXR associated with agonist
1) Confidence 0.45 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.29 Pain Relevance 0.33
The RXR/PPAR heterodimer is activated by
Positive_regulation (/) of Gene_expression (heterodimer) of RXR
2) Confidence 0.45 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
The RXR/PPAR heterodimer is activated by
Positive_regulation (activated) of Gene_expression (heterodimer) of RXR
3) Confidence 0.45 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
sterility observed in RXR?
Positive_regulation (observed) of Gene_expression (observed) of RXR associated with infertility
4) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266973 Disease Relevance 0.16 Pain Relevance 0
Manipulation of RAR/RXR signaling in the peripheral nervous system
Positive_regulation (Manipulation) of Gene_expression (/) of RXR in peripheral nervous system associated with peripheral nervous system
5) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.46 Pain Relevance 0.32
About 500 genes have been suggested to be regulated by RAR/RXR
Positive_regulation (by) of Gene_expression (/) of RXR
6) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.75 Pain Relevance 0.15
in the absence of ligand, and that RXR agonists enhanced the interaction, suggesting that RXR interacts with ?
Positive_regulation (enhanced) of Gene_expression (agonists) of RXR associated with agonist
7) Confidence 0.10 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.83 Pain Relevance 0.10
Similarly, action of vitamin A, so called retinol, is mediated over antigen presenting cells (APC) through specific intracellular retinoid acid receptors (RAR) [10] and retinoid × receptors (RXR)[11], which are present in the immune cells [12].
Positive_regulation (mediated) of Gene_expression (presenting) of RXR in immune cells
8) Confidence 0.08 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.92 Pain Relevance 0.21
, which becomes the main RXR partner throughout the adipogenesis, coinciding with a significant increase in both PPAR?
Positive_regulation (becomes) of Gene_expression (partner) of RXR
9) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.09 Pain Relevance 0
, which becomes the main RXR partner throughout the adipogenesis, coinciding with a significant increase in both PPAR?
Positive_regulation (main) of Gene_expression (partner) of RXR
10) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.09 Pain Relevance 0
, which becomes the main RXR partner throughout the adipogenesis, coincided with a significant increase in both PPAR?
Positive_regulation (main) of Gene_expression (partner) of RXR
11) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.22 Pain Relevance 0
, which becomes the main RXR partner throughout the adipogenesis, coincided with a significant increase in both PPAR?
Positive_regulation (becomes) of Gene_expression (partner) of RXR
12) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.22 Pain Relevance 0
Moreover, MK866 increased the expression of RXR?
Positive_regulation (increased) of Gene_expression (expression) of RXR
13) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.21 Pain Relevance 0.17
These results are generally consistent with what has been observed in conjunction with the overexpression of adipogenesis- and osteogenesis-related transcription factors, including RXR, osteonectin, AP, and PPAR-gamma, after de-differentiation (Figure 5A).
Positive_regulation (overexpression) of Gene_expression (overexpression) of RXR
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.35 Pain Relevance 0

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