INT199764

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Gstp1) protein complex (Gstp1)
Anatomy Link Frequency
fibroblasts 2
Gstp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 6 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
local anesthetic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 3 99.68 Very High Very High Very High
Nicotine Addiction 204 99.52 Very High Very High Very High
Bronchogenic Carcinoma 6 97.08 Very High Very High Very High
Apoptosis 3 95.16 Very High Very High Very High
Pulmonary Disease 9 82.84 Quite High
Lung Cancer 18 81.56 Quite High
Cancer 3 39.16 Quite Low
Toxicity 6 5.00 Very Low Very Low Very Low
Asthma 6 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, increased expression of GSTP1 in healthy smokers might protect against accumulation of carcinogens.


Positive_regulation (increased) of Gene_expression (expression) of GSTP1 associated with nicotine addiction
1) Confidence 0.55 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.74 Pain Relevance 0
GSTP1 overexpression inhibited cytotoxic effects of cigarette smoke extract on human fibroblast-derived cells and depletion of GSTP1-induced apoptosis in lung fibroblasts (Ishii et al. 2001, 2003).
Positive_regulation (overexpression) of Gene_expression (overexpression) of GSTP1 in fibroblasts associated with apoptosis
2) Confidence 0.55 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.97 Pain Relevance 0
Gene expression of CYP1A1, CYP1B1, CYP2S1, GSTP1, and EPHX1 was induced in bronchoalveolar lavage cells of smokers, whereas expression of CYP2B6/7, CYP3A5, and UGT2A1 was repressed.
Positive_regulation (induced) of Gene_expression (expression) of GSTP1 associated with nicotine addiction
3) Confidence 0.37 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1665420 Disease Relevance 0.50 Pain Relevance 0

General Comments

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