INT199766

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2006
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppib) protein folding (Ppib) endoplasmic reticulum (Ppib)
Anatomy Link Frequency
lung 2
Ppib (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 6 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
local anesthetic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 204 98.68 Very High Very High Very High
Toxicity 6 94.84 High High
Bronchogenic Carcinoma 6 73.76 Quite High
Lung Cancer 18 64.44 Quite High
Pulmonary Disease 9 5.00 Very Low Very Low Very Low
Asthma 6 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lung tissue and cell types within the lung differ in their capacity to oxidize xenobiotics (Hecht 1999) because CYPs are not uniformly expressed (Ding and Karminsky 2003).
Neg (not) Gene_expression (expressed) of CYPs in lung
1) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.55 Pain Relevance 0
Gene expression of CYPs and FMOs
Gene_expression (expression) of CYPs
2) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.48 Pain Relevance 0
We investigated the gene expression of 19 cytochrome P450 monooxygenases (CYPs) and 3 flavin-containing monooxygenases (FMOs), as well as uridine diphosphate glucuronosyltransferase (UGT) 2A1 (UGT2A1), epoxide hydrolase (EPHX1), glutathione-S-transferase (GST) A2 (GSTA2), GSTP1, and GSTM1 in lung cells obtained from bronchoalveolar lavage (BAL) fluid and in bronchial biopsies (BBs) of smokers (n = 8) and nonsmokers (n = 10).
Spec (investigated) Gene_expression (expression) of CYPs in lung associated with nicotine addiction
3) Confidence 0.58 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.67 Pain Relevance 0

General Comments

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