INT199771

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.86
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
nucleus 2
midline 2
DCs 1
lung 1
mast cell 1
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 31 100.00 Very High Very High Very High
Inflammation 53 94.00 High High
chemokine 5 34.32 Quite Low
agonist 24 5.00 Very Low Very Low Very Low
Bile 22 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
complementary and alternative medicine 10 5.00 Very Low Very Low Very Low
lidocaine 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 132 100.00 Very High Very High Very High
Eosinophilia 19 100.00 Very High Very High Very High
Pulmonary Eosinophilia 1 98.72 Very High Very High Very High
Cough 1 96.40 Very High Very High Very High
Rhinitis 39 95.48 Very High Very High Very High
INFLAMMATION 53 94.00 High High
Nicotine Addiction 144 92.64 High High
Chronic Disease 1 92.64 High High
Eczema 13 91.76 High High
Prostate Cancer 56 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once these xenobiotics are recognized by AhR, the AhR–ligand complexes translocate into the nucleus and form heterodimers with its partner coactivator, AhR nuclear translocator (Arnt).
Localization (translocate) of AhR in nucleus
1) Confidence 0.70 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.34 Pain Relevance 0
-catenin along with the upregulation of AhR (Figure 5D), it is possible that the cause of AhR elevation following ?
Localization (cause) of AhR
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.79 Pain Relevance 0.07
AHR is a member of the Per-AhR/Arnt-Sim homology sequence (PAS)/basic helix-loop-helix (HLH) superfamily, which also represents the period regulator of circadian rhythm (PER), Ah receptor nuclear translocator (ARNT), and single-minded regulator of midline cell differentiation.
Localization (translocator) of AHR in midline
3) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.39 Pain Relevance 0
AHR is a member of the Per-AhR/Arnt-Sim homology sequence (PAS)/basic helix-loop-helix (HLH) superfamily, which also represents the period regulator of circadian rhythm (PER), Ah receptor nuclear translocator (ARNT), and single-minded regulator of midline cell differentiation.
Localization (translocator) of AhR in midline
4) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.33 Pain Relevance 0
Upon translocation into the nucleus, the AHR forms a heterodimer with its nuclear counterpart ARNT (AHR nuclear translocator) and drives gene expression of the AHR-responsible gene family, including CYP1A1 and CYP1B1 (Borlak and Thum 2001).
Localization (translocator) of AHR in nucleus
5) Confidence 0.52 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.37 Pain Relevance 0
Although we did not observe changes of the AHR at the gene expression level, Martey et al. (2005) recently reported that cigarette smoke extract led to an activation of the AHR in cultured human lung fibroblasts based on induced nuclear translocation of the AHR (Martey et al. 2005).
Localization (translocation) of AHR in lung
6) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.23 Pain Relevance 0
In subsequent studies, however, mepolizumab therapy reduced exacerbations and improved AQLQ scores in patients with refractory eosinophilic asthma,57 It also reduced the number of blood and sputum eosinophils and allowed prednisone sparing in patients who had asthma with sputum eosinophilia despite prednisone treatment.58 Indeed, clinical studies have shown that AHR correlates with mast cell localization near pulmonary nerves, whereas pulmonary eosinophilia relates more strongly with chronic cough.59

2.

Localization (localization) of AHR in mast cell associated with asthma, rhinitis, cough, pulmonary eosinophilia and eosinophilia
7) Confidence 0.21 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.84 Pain Relevance 0.04
We previously demonstrated that IL-10-treated dendritic cells (DCs) can abrogate asthmatic responses in mice, including airway hyperresponsiveness (AHR), eosinophilia, Th2 cytokine secretion, and serum IgE/IgG1.
Localization (secretion) of AHR in DCs associated with asthma, eosinophilia and cytokine
8) Confidence 0.15 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox