INT199781

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
CAR 2
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
Versed 4 41.84 Quite Low
drug abuse 2 29.12 Quite Low
Nicotine 4 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 136 98.60 Very High Very High Very High
Carcinoma 2 80.24 Quite High
Bronchogenic Carcinoma 4 77.64 Quite High
Hypersensitivity 2 71.12 Quite High
Apoptosis 2 69.88 Quite High
Disease 2 69.68 Quite High
Toxicity 4 58.64 Quite High
Pulmonary Disease 6 46.72 Quite Low
Lung Cancer 12 45.44 Quite Low
Drug Dependence 2 29.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore studied expression of the aryl hydrocarbon receptor (AHR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), liver X receptor (LXR), and glucocorticoid receptor (GR) (Gibson et al. 2002; Tirona et al. 2003) for their established role in CYP gene regulation in BAL cells and BBs derived from smokers and nonsmokers.
Regulation (role) of Regulation (regulation) of CYP in CAR associated with nicotine addiction
1) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.57 Pain Relevance 0
CYP regulation is, in most cases, not dependent only on a specific nuclear factor, but requires a complex network of interacting factors (Waxman 1999).


Neg (not) Regulation (dependent) of Regulation (regulation) of CYP
2) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.57 Pain Relevance 0

General Comments

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