INT199789

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2J2) endoplasmic reticulum (CYP2J2)
Anatomy Link Frequency
lung 2
hearts 2
CYP2J2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 99.96 Very High Very High Very High
Inflammation 2 66.80 Quite High
Nicotine 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 99.96 Very High Very High Very High
Reperfusion Injury 1 99.60 Very High Very High Very High
Nicotine Addiction 136 99.56 Very High Very High Very High
Myocardial Infarction 9 94.80 High High
Increased Venous Pressure Under Development 2 90.44 High High
Pulmonary Disease 6 78.84 Quite High
Asthma 4 76.40 Quite High
INFLAMMATION 2 66.80 Quite High
Cardiovascular Disease 3 66.00 Quite High
Coronary Heart Disease 1 51.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In smokers, expression of CYP1A1 (p < 0.05), CYP1B1 (p < 0.001), and CYP2C9 (p < 0.05) was increased (p < 0.05) compared with non-smokers, and there was a trend toward increased expression of CYP3A5 (p = 0.0545; Figure 1); however, the expression of CYP2J2 was significantly (p < 0.05) repressed.
Negative_regulation (repressed) of Gene_expression (expression) of CYP2J2 associated with nicotine addiction
1) Confidence 0.41 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.79 Pain Relevance 0
Increased expression of CYP2J2 in mice hearts decreases ischemia-reperfusion damage through production of EETs which affect the KATP channel activity and MAP kinase signalling.[25]
Negative_regulation (decreases) of Gene_expression (expression) of CYP2J2 in hearts associated with reperfusion injury and ischemia
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.64 Pain Relevance 0.08
In the present study, we observed reduced expression of CYP2J2 in BBs of smokers, whereas CYP2C9 was significantly induced in this lung compartment.
Negative_regulation (reduced) of Gene_expression (expression) of CYP2J2 in lung associated with nicotine addiction
3) Confidence 0.30 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.72 Pain Relevance 0

General Comments

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