INT199793

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 27
Disease Relevance 19.60
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2J2) endoplasmic reticulum (CYP2J2)
Anatomy Link Frequency
heart 7
lung 3
cardiomyocytes 2
endothelial cells 2
stroma 1
CYP2J2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 24 98.96 Very High Very High Very High
antagonist 120 91.40 High High
Inflammation 513 80.64 Quite High
Calcium channel 18 63.04 Quite High
Angina 9 32.76 Quite Low
agonist 90 5.00 Very Low Very Low Very Low
cytokine 30 5.00 Very Low Very Low Very Low
chemokine 30 5.00 Very Low Very Low Very Low
COX2 15 5.00 Very Low Very Low Very Low
fibrosis 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1743 100.00 Very High Very High Very High
Renal Cancer 15 99.82 Very High Very High Very High
Prostate Cancer 105 99.60 Very High Very High Very High
Nicotine Addiction 204 99.56 Very High Very High Very High
Malignant Neoplastic Disease 45 99.28 Very High Very High Very High
Cv Unclassified Under Development 24 98.96 Very High Very High Very High
Reperfusion Injury 9 98.60 Very High Very High Very High
Carcinoma 48 98.56 Very High Very High Very High
Skin Cancer 15 98.44 Very High Very High Very High
Apoptosis 42 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of CYP2J2 in mice hearts decreases ischemia-reperfusion damage through production of EETs which affect the KATP channel activity and MAP kinase signalling.[25]
Gene_expression (expression) of CYP2J2 in hearts associated with reperfusion injury and ischemia
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.64 Pain Relevance 0.08
Using immunoblotting techniques, Zeldin's group reported in 1996 that CYP2J2 was highly expressed in human heart tissues.[11] Their study was followed by Thum and Borlak's study using RT-PCR, which suggested that several CYP450s were expressed in the human heart.[10] Drawing on data obtained from 7 explanted hearts from heart failure patients and 2 hearts from normal subjects, they reported that the presence of CYP1A1, CYP2B6, CYP2C8, CYP2C19, CYP2D6 and CYP4B1 mRNAs.
Gene_expression (expressed) of CYP2J2 in heart associated with myocardial infarction
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.26 Pain Relevance 0
Results obtained by immunohistochemistry analyses demonstrate that CYP450 proteins such as CYP2J2 and CYP2Cs are expressed in human cardiomyocytes.
Gene_expression (expressed) of CYP2J2 in cardiomyocytes
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.07 Pain Relevance 0
Primary antibody negative controls and CYP450 antibody positive staining results clearly indicated that CYP2J2 and CYP2Cs proteins were expressed in human cardiomyocytes (Figure 4).
Gene_expression (expressed) of CYP2J2 in cardiomyocytes
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.05 Pain Relevance 0
In particular, while liver microsomes express low levels of CYP2J2 and are therefore not taken into account in routine drug-drug interaction screening, CYP2J2 is highly expressed in the heart and could be extremely relevant for the local clearance of drugs and metabolite formation in the heart.


Gene_expression (express) of CYP2J2 in heart
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0.03
In particular, while liver microsomes express low levels of CYP2J2 and are therefore not taken into account in routine drug-drug interaction screening, CYP2J2 is highly expressed in the heart and could be extremely relevant for the local clearance of drugs and metabolite formation in the heart.


Gene_expression (expressed) of CYP2J2 in heart
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.06 Pain Relevance 0.03
3), they further demonstrated that gene expression for CYP2J2 and CYP1A1 was the most abundant.[26] They confirmed these results in 11 diseased and 2 normal human hearts, showing that CYP450 gene expression in the left ventricle was limited to CYP1A1, CYP2A6, CYP2B6, CYP2C8, CYP2E1, CYP2J2 and CYP4A11.[21] Recent studies conducted with quantitative real-time PCR and samples from 8 explanted human hearts indicated that CYP2J2 mRNA values were >900 times higher than those measured for CYP2C9 or CYP2C8.[12] Our results, obtained in a large cohort of human hearts, support data from these pilot studies and confirm high CYP2J2 mRNA levels in human hearts.
Gene_expression (expression) of CYP2J2 in hearts
7) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.16 Pain Relevance 0
Furthermore, our access to a large number of human hearts enabled us to demonstrate high inter-subject variability, especially for CYP2J2 and CYP1A1 mRNA levels.
Gene_expression (levels) of CYP2J2 in hearts
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.21 Pain Relevance 0
In smokers, expression of CYP1A1 (p < 0.05), CYP1B1 (p < 0.001), and CYP2C9 (p < 0.05) was increased (p < 0.05) compared with non-smokers, and there was a trend toward increased expression of CYP3A5 (p = 0.0545; Figure 1); however, the expression of CYP2J2 was significantly (p < 0.05) repressed.
Gene_expression (expression) of CYP2J2 associated with nicotine addiction
9) Confidence 0.55 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.73 Pain Relevance 0
Expression of CYP1A1 (p < 0.01), CYP1B1 (p < 0.001), and CYP2S1 (p < 0.001) was higher in BAL cells from smokers compared with those of nonsmokers (Figure 1), whereas expression of CYP2B6/7 (p < 0.01) and CYP3A5 (p < 0.001) was lower; expression of CYP2A6/7, CYP2E1, CYP2C9, CYP2J2, and FMO5 was not altered.
Gene_expression (expression) of CYP2J2 associated with nicotine addiction
10) Confidence 0.55 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.76 Pain Relevance 0
In particular, while liver microsomes express low levels of CYP2J2 and are therefore not taken into account in routine drug-drug interaction screening, CYP2J2 is highly expressed in the heart and could be extremely relevant for the local clearance of drugs and metabolite formation in the heart.


Gene_expression (levels) of CYP2J2 in heart
11) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0.03
The overexpression of CYP epoxygenases, including CYP2J2, also increased muscle capillary density in a rat ischemic hind limb model [103].
Gene_expression (overexpression) of CYP2J2 in hind limb
12) Confidence 0.51 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.10 Pain Relevance 0
Furthermore, CYP2J2 expression was detected in less than 50% of lung squamous cell carcinoma samples and in less than 15% of lung adenocarcinoma samples [127].
Gene_expression (expression) of CYP2J2 in lung associated with adenocarcinoma and skin cancer
13) Confidence 0.51 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.28 Pain Relevance 0
Subsequent studies, in which CYP epoxygenase levels were manipulated, by either overexpression of CYP2J2 or antisense in the xenotransplanted tumor cell, suggest EETs may play a role in cancer metastasis [121].
Gene_expression (overexpression) of CYP2J2 associated with cancer and metastasis
14) Confidence 0.51 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.43 Pain Relevance 0
CYP2C9 was the most abundantly expressed epoxygenase in several human malignant neoplasms [127].
Gene_expression (expressed) of epoxygenase associated with malignant neoplastic disease
15) Confidence 0.51 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.21 Pain Relevance 0
Enayetallah et al. analyzed three cytochrome P450 epoxygenases (CYP2C8, CYP2C9, and CYP2J2) and soluble epoxide hydrolase in human malignant neoplasms [127].
Spec (analyzed) Gene_expression (analyzed) of CYP2J2 associated with malignant neoplastic disease
16) Confidence 0.44 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.32 Pain Relevance 0
In the present study, we observed reduced expression of CYP2J2 in BBs of smokers, whereas CYP2C9 was significantly induced in this lung compartment.
Gene_expression (expression) of CYP2J2 in lung associated with nicotine addiction
17) Confidence 0.43 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.72 Pain Relevance 0
Additionally, monocytic leukocytes have recently been shown to express CYP2J2 and therefore, may generate EETs [43].
Gene_expression (express) of CYP2J2 in leukocytes
18) Confidence 0.40 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.13 Pain Relevance 0.07
For instance, CYP2C8, CYP2C9, and CYP2J2 were recently shown to be expressed in three prostate carcinoma cell lines (PC3, DU-145, and LNCaP) [125].
Gene_expression (expressed) of CYP2J2 associated with prostate cancer
19) Confidence 0.40 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.36 Pain Relevance 0.09
EETs are primarily synthesized in endothelial cells which express isoforms of CYP2C and CYP2J (e.g., CYP2C9 and CYP2J2) [10, 34–37].
Gene_expression (express) of CYP2J in endothelial cells
20) Confidence 0.40 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.20 Pain Relevance 0.08

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