INT199809

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 13.26
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 2
blood 1
platelet 1
forebrain 1
skin 1
hb (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 345 99.56 Very High Very High Very High
Hippocampus 42 94.44 High High
Neurobehavioral 12 94.40 High High
Central nervous system 22 91.76 High High
depression 18 91.76 High High
alcohol 9 91.60 High High
cytokine 37 87.16 High High
Dopamine 66 82.16 Quite High
Serotonin 12 81.12 Quite High
monoamine 78 62.08 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 660 99.96 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 345 99.56 Very High Very High Very High
Ganglion Cysts 6 99.24 Very High Very High Very High
Pulmonary Disease 320 98.00 Very High Very High Very High
Anaemia 267 96.20 Very High Very High Very High
Body Weight 23 96.08 Very High Very High Very High
Death 4 95.88 Very High Very High Very High
Cancer 235 93.76 High High
Congenital Anomalies 70 93.44 High High
Heart Disease 2 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The animals exposed to lead showed significant decrease in RBC and Hb level.
Negative_regulation (decrease) of Hb
1) Confidence 0.36 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964740 Disease Relevance 0.19 Pain Relevance 0
It is well known that the presence of lead in the organism decreases the level of iron in the blood and causes the decrease in Hb concentration.
Negative_regulation (decrease) of Hb in blood
2) Confidence 0.36 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964740 Disease Relevance 0.63 Pain Relevance 0
We generated mice in which HB-EGF activity is disrupted specifically in the ventral forebrain.
Negative_regulation (disrupted) of HB-EGF in ventral
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.54 Pain Relevance 0.17
In the current study, therefore, we have generated HB-EGF conditional knockout (KO) mice that exhibit disruption of HB-EGF activity specifically in the ventral forebrain.
Negative_regulation (disruption) of HB-EGF in forebrain associated with targeted disruption
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.76 Pain Relevance 0.18
Despite the decreased expression HB-EGF, the overall development of HB-EGF KO mice appeared to be normal and there were no significant differences in the body weight in the adult KO or control mice.
Negative_regulation (decreased) of HB-EGF in body associated with targeted disruption and body weight
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.20 Pain Relevance 0.05
During a 10 min social interaction test in a novel environment, the mean duration per contact was significantly less in HB-EGF KO mice than in control mice, indicating that HB-EGF KO mice spent significantly less time engaging in social contact (P<0.05 vs. control mice) (Fig. 2d).
Negative_regulation (less) of HB-EGF associated with targeted disruption
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.97 Pain Relevance 0
Next, to further assess the specificity of changes in working memory related to the loss of HB-EGF protein, we elected to test spontaneous alternation in the Y-maze, which is devoid of any procedural bias because it is based on the natural tendency of mice to explore a novel environment.
Negative_regulation (loss) of HB-EGF
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.87 Pain Relevance 0.06
Additionally, we confirmed the disruption of Hb-egf gene by lacZ staining.
Negative_regulation (disruption) of Hb-egf
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.78 Pain Relevance 0.15
This study gives support for the selection of patients for treatment who start to decline in Hb level early in a series of cytostatic treatments.
Negative_regulation (decline) of Hb
9) Confidence 0.24 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.52 Pain Relevance 0.06
Normalization of Hb levels in incident hemodialysis patients does not have a beneficial effect on cardiac structure (Parfrey et al 2005).
Negative_regulation (Normalization) of Hb
10) Confidence 0.22 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.86 Pain Relevance 0
12 g/dl to prevent further decline in Hb in patients with falling Hb levels and a planned further cytostatic treatment with a high risk of worsening anemia.
Negative_regulation (decline) of Hb associated with anaemia
11) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.56 Pain Relevance 0
Further stratifying the subjects by intensity of exposure, we found a significant linear trend between severity of exposure and reduction of RBCs and HB in both males and females.
Negative_regulation (reduction) of HB
12) Confidence 0.18 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665423 Disease Relevance 0.26 Pain Relevance 0.05
In the present study, unbiased proteomics and subsequent MS and Western blot analyses indicated reduced levels of Hb (?
Negative_regulation (reduced) of Hb
13) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.45 Pain Relevance 0.09
In the IPF lungs, only a modest reduction of the Hb?
Negative_regulation (reduction) of Hb in lungs associated with fibrosis
14) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.60 Pain Relevance 0.20
Decline of Hb complexes and monomers in the IPF but not in the COPD lungs
Negative_regulation (Decline) of Hb in lungs associated with fibrosis and pulmonary disease
15) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.10 Pain Relevance 0.24
The underlying skin of the mouse was removed, and the gels were recovered for hemoglobin (Hb) measurement using the Drabkin reagent kit (Sigma).
Negative_regulation (recovered) of Hb in skin
16) Confidence 0.16 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 0.15 Pain Relevance 0.03
First, there is a significant decrease in RBC count and HB in the exposed residents ?
Negative_regulation (decrease) of HB
17) Confidence 0.15 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665423 Disease Relevance 0.09 Pain Relevance 0
Prevention of Hb?
Negative_regulation (Prevention) of Hb
18) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.73 Pain Relevance 0.23
Loss of Hb?
Negative_regulation (Loss) of Hb
19) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.02 Pain Relevance 0.29
Although the respiratory symptoms of exposed residents were consistent with those in previous reports of Halon exposure (Brooks et al. 1985; De La Hoz 1999; Holness and House 1992; Kaufman et al. 1992), we wondered why there were decreases in RBC and HB.
Negative_regulation (decreases) of HB in respiratory
20) Confidence 0.13 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665423 Disease Relevance 0.68 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox