INT199845

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.14
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gem) plasma membrane (Gem) GTPase activity (Gem)
Anatomy Link Frequency
dendritic cell 1
Gem (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 97.08 Very High Very High Very High
chemokine 6 96.86 Very High Very High Very High
Central nervous system 30 90.36 High High
Inflammation 68 21.96 Low Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 8 99.84 Very High Very High Very High
Apoptosis 60 99.64 Very High Very High Very High
Non-small-cell Lung Cancer 16 99.12 Very High Very High Very High
Cancer 46 98.68 Very High Very High Very High
Lung Cancer 10 71.32 Quite High
Leukemia 2 70.08 Quite High
Reprotox - General 1 4 69.28 Quite High
Colon Cancer 1 67.68 Quite High
Death 28 50.00 Quite Low
INFLAMMATION 74 21.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These genes can be divided into: a) those already upregulated by LPS, such as chemokines, cytokines, JAK-STAT pathway, regulators of transcription and others; b) genes only induced when LPS is combined to RU486, namely a cell-surface antigen of activated dendritic cell (Cd83), a GTPase of the RGK family (Gem) and a transcription factor of the CNC-bZip family (Bach1).
Positive_regulation (activated) of Gem in dendritic cell associated with chemokine and cytokine
1) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.09 Pain Relevance 0.10
These included acute-phase reactants (APRs) (Saa3, Lcn2 and Serpina3n), genes with GR-mediated repression on LPS induction (Gem, Cd83 and Tnfsf9) and other transcripts modulated by GR signaling.
Positive_regulation (induction) of Gem associated with repression
2) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.10 Pain Relevance 0.10
We demonstrated that PB effectively increased GEM induced apoptosis in NSCLC cell cancer cell lines both in vitro and in vivo.
Positive_regulation (increased) of GEM associated with cancer, non-small-cell lung cancer and apoptosis
3) Confidence 0.20 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 0.95 Pain Relevance 0

General Comments

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