INT199848

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.29
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)
Anatomy Link Frequency
Cleavage 1
nucleus 1
Casp8 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 94.00 High High
addiction 1 80.48 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 27 100.00 Very High Very High Very High
Apoptosis 140 99.90 Very High Very High Very High
Necrosis 4 97.28 Very High Very High Very High
Cancer 175 96.92 Very High Very High Very High
Pancreatic Cancer 61 74.44 Quite High
Stress 2 72.88 Quite High
Carcinoma 19 70.36 Quite High
Metastasis 21 63.00 Quite High
Disease 2 50.68 Quite High
Non-small-cell Lung Cancer 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, a direct association between ERK and a DED-containing fragment of caspase-8, and co-transport of an ERK-caspase-8-DED complex to the nucleus during apoptosis has been reported [36].
caspase-8 Binding (association) of in nucleus associated with apoptosis
1) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 1.05 Pain Relevance 0
can induce apoptosis via recruiting TNFR-associated death domain protein (TRADD), FADD, and Caspase-8, and then modulate Caspase-9 and Caspase-3.
Caspase-8 Binding (recruiting) of associated with apoptosis and death
2) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.23 Pain Relevance 0.05
Cleavage of caspase-8 and Bid was low in KNS62 cells after GEM and PB treatment alone, but significantly increased with combination therapy (Fig. 3a).
caspase-8 Binding (Cleavage) of in Cleavage
3) Confidence 0.06 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 1.01 Pain Relevance 0.04

General Comments

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