INT199856

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.46
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
cleavage 2
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 97.08 Very High Very High Very High
cva 1 78.24 Quite High
cytokine 10 61.52 Quite High
Inflammation 23 61.16 Quite High
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 60 100.00 Very High Very High Very High
Death 16 97.78 Very High Very High Very High
Lung Injury 102 91.72 High High
Hemorrhage 1 78.24 Quite High
Adult Respiratory Distress Syndrome 25 75.64 Quite High
INFLAMMATION 25 61.16 Quite High
Urological Neuroanatomy 9 59.48 Quite High
Non-small-cell Lung Cancer 16 50.00 Quite Low
Exsanguination 1 49.40 Quite Low
Volume Depletion And Dehydration 1 44.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PARP activity assay and administration of PARP inhibitor
Negative_regulation (inhibitor) of Protein_catabolism (administration) of PARP
1) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.51 Pain Relevance 0.10
The dependence of chemotherapy-induced cell death on caspase-mediated apoptotic pathways was confirmed by the observation that the broad caspase-inhibitor zVAD prevented apoptosis-related DNA fragmentation and PARP cleavage in treated cells (Fig. 3b+c).
Negative_regulation (prevented) of Protein_catabolism (cleavage) of PARP in cleavage associated with addiction, apoptosis and death
2) Confidence 0.13 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 0.96 Pain Relevance 0.05

General Comments

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