INT19986

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 4.32
Pain Relevance 24.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
mossy fiber 7
platelet 3
pyramidal cell 1
dentate gyrus 1
cerebral cortex 1
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 684 100.00 Very High Very High Very High
antagonist 109 100.00 Very High Very High Very High
Dynorphin 45 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
nMDA receptor antagonist 3 99.96 Very High Very High Very High
Somatostatin 47 99.92 Very High Very High Very High
narcan 10 99.84 Very High Very High Very High
Enkephalin 76 99.78 Very High Very High Very High
Antinociceptive 6 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 30 98.80 Very High Very High Very High
Gallstones 8 98.52 Very High Very High Very High
Targeted Disruption 5 93.12 High High
Morphine Dependence 2 91.68 High High
Amyloid Plaque 2 91.52 High High
Epilepsy 3 88.92 High High
Stress 5 85.84 High High
Ganglion Cysts 6 84.48 Quite High
Nervous System Injury 3 78.64 Quite High
Alzheimer's Dementia 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four days after injections of 0.2 or 0.25 microgram kainic acid, mossy fiber ENK-I was greatly elevated, dynorphin immunoreactivity was reduced, but, unlike the situation with lower kainic acid doses, CCK-I was only modestly reduced in the mossy fibers and was clearly reduced in other hippocampal systems as well.
Negative_regulation (reduced) of CCK-I in mossy fiber associated with dynorphin and cholecystokinin
1) Confidence 0.59 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.07 Pain Relevance 0.50
Simultaneously, the number of CCK-8, benzodiazepine and GABA-A receptors in cerebral cortex was decreased.
Negative_regulation (number) of CCK-8 in cerebral cortex associated with gaba and cerebral cortex
2) Confidence 0.55 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2111914 Disease Relevance 0 Pain Relevance 0.69
CCK-A receptor inactivation with its antagonist devazepide prevented the anorexigenic effect of CART(61-102) (0.1 and 0.5 ?
Negative_regulation (inactivation) of CCK associated with antagonist and cholecystokinin
3) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.48
In contrast, cholecystokinin was decreased in mossy fibers.
Negative_regulation (decreased) of cholecystokinin in mossy fibers associated with cholecystokinin
4) Confidence 0.45 Published 2003 Journal Neurobiol. Dis. Section Abstract Doc Link 14678773 Disease Relevance 0.47 Pain Relevance 0.78
The antinociceptive effect of cholecystokinin was reversed by naloxone, suggesting that the antinociceptive action involves endogenous opioid peptides in its production.
Negative_regulation (reversed) of cholecystokinin associated with endogenous opioid, narcan, cholecystokinin and antinociceptive
5) Confidence 0.43 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2859382 Disease Relevance 0 Pain Relevance 0.94
Four days after injections of 0.2 or 0.25 microgram kainic acid, mossy fiber ENK-I was greatly elevated, dynorphin immunoreactivity was reduced, but, unlike the situation with lower kainic acid doses, CCK-I was only modestly reduced in the mossy fibers and was clearly reduced in other hippocampal systems as well.
Negative_regulation (reduced) of CCK-I in mossy fiber associated with dynorphin and cholecystokinin
6) Confidence 0.43 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.07 Pain Relevance 0.50
In contrast, the loss of CCK seemed restricted to the mossy fiber system in that immunostaining appeared normal in scattered hippocampal perikarya, within the dentate gyrus commissural system, as well as within other limbic structures.
Negative_regulation (loss) of CCK in dentate gyrus associated with cholecystokinin
7) Confidence 0.43 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.20 Pain Relevance 0.72
CCK8 (1 microgram/mouse) markedly stimulated the 2-DG uptake in neurons in the various regions of the brain, but the stimulative effects of CCK8 was almost completely suppressed after an intraperitoneal administration of 1.0 mg/kg of DZP or 0.5 mg/kg of ATM.
Negative_regulation (suppressed) of CCK8 in brain
8) Confidence 0.43 Published 1988 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3199597 Disease Relevance 0 Pain Relevance 0.20
Four days after either lesion placement or injection of 0.05-0.1 microgram kainic acid, immunoreactivity for all 3 peptides was altered throughout the intact mossy fiber system, bilaterally, but in distinctly different ways: enkephalin immunoreactivity (ENK-I) was dramatically elevated, dynorphin immunoreactivity was reduced, and CCK immunoreactivity (CCK-I) was either severely reduced or completely absent in the mossy fiber system.
Negative_regulation (reduced) of CCK immunoreactivity in mossy fiber associated with dynorphin, enkephalin and cholecystokinin
9) Confidence 0.43 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.22 Pain Relevance 0.73
Four days after either lesion placement or injection of 0.05-0.1 microgram kainic acid, immunoreactivity for all 3 peptides was altered throughout the intact mossy fiber system, bilaterally, but in distinctly different ways: enkephalin immunoreactivity (ENK-I) was dramatically elevated, dynorphin immunoreactivity was reduced, and CCK immunoreactivity (CCK-I) was either severely reduced or completely absent in the mossy fiber system.
Negative_regulation (reduced) of CCK-I in mossy fiber associated with dynorphin, enkephalin and cholecystokinin
10) Confidence 0.43 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2898512 Disease Relevance 0.22 Pain Relevance 0.73
Immunocytochemical analyses of enkephalin-(ENK-I) and cholecystokinin-immunoreactivity (CCK-I) in contralateral hippocampus of animals sacrificed at various postlesion intervals revealed that both ENK-I and CCK-I were depleted from the mossy fibers at 6 and 12 hr postlesion, and that ENK-I rebounded to supranormal levels by 27 hr.
Negative_regulation (depleted) of CCK-I in mossy fibers associated with hippocampus, enkephalin and cholecystokinin
11) Confidence 0.43 Published 1988 Journal Peptides Section Abstract Doc Link 2856653 Disease Relevance 0.47 Pain Relevance 0.52
The inhibition of jumping induced by caerulein was reduced with the selective cholecystokinin antagonists MK-329 and L-365,260.
Negative_regulation (reduced) of cholecystokinin associated with antagonist and cholecystokinin
12) Confidence 0.42 Published 1995 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8835359 Disease Relevance 0.24 Pain Relevance 1.62
Our aim was to test whether abolishing the endogenous CCK tone might influence the cannabinoid-mediated form of SIA.
Negative_regulation (abolishing) of CCK associated with cannabinoid, cholecystokinin and analgesia
13) Confidence 0.42 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18412633 Disease Relevance 0.24 Pain Relevance 1.80
These data further support the involvement of opioid receptors in the antidepressant-type effect induced by CCK(B) receptor blockers and support the hypothesis of a regulatory role of CCK in the activity of the endogenous opioid system.
Negative_regulation (blockers) of CCK associated with antidepressant, endogenous opioid and opioid receptor
14) Confidence 0.42 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016909 Disease Relevance 0 Pain Relevance 0.80
Devazepide (L364,718), a selective antagonist of CCKA receptors, effectively blocked the action of CCK8(s), but not that of CCK4(30-33) or SNF 9007 (phase I).
Negative_regulation (antagonist) of CCK associated with antagonist
15) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.47
Relationship between CCK and the CART peptide was documented also at pancreatic exocrine secretion of amylase where the stimulating effect of CART peptide was inhibited in vivo but not in vitro by CCK-A receptor antagonist devazepide [26].
Negative_regulation (documented) of CCK associated with antagonist and cholecystokinin
16) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.19 Pain Relevance 0.64
This pathway could contribute to the additive effect of CCK and CART peptide in the DMH.
Negative_regulation (effect) of CCK associated with cholecystokinin
17) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.72
In contrast, in positive control experiments, the inhibitory effects of CCK, SNF9019, and SNF9007 on gastrointestinal propulsion in mice were antagonized by identical i.c.v. doses of L364,718 and L365,260.
Negative_regulation (effects) of CCK
18) Confidence 0.40 Published 1997 Journal Peptides Section Abstract Doc Link 9145429 Disease Relevance 0 Pain Relevance 1.01
In CD-1 mice, a linear sequence of dynorphin A(1-17) --> cholecystokinin --> LE --> NMDA receptors was indicated: cholecystokinin antiserum inhibited cholecystokinin but not LE; naltriben inhibited LE but not NMDA.
Negative_regulation (inhibited) of cholecystokinin associated with dynorphin, nmda receptor, enkephalin and cholecystokinin
19) Confidence 0.39 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303046 Disease Relevance 0 Pain Relevance 2.74
Pretreatment with intrathecal LE antiserum eliminated dynorphin and cholecystokinin-8s antianalgesia.
Negative_regulation (eliminated) of cholecystokinin associated with dynorphin, enkephalin, cholecystokinin and intrathecal
20) Confidence 0.39 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303046 Disease Relevance 0 Pain Relevance 1.67

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