INT199874

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.31
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 27 100.00 Very High Very High Very High
Inflammation 66 97.88 Very High Very High Very High
cytokine 4 90.32 High High
Crohn's disease 1 90.04 High High
Arthritis 58 89.48 High High
Demyelination 1 77.40 Quite High
Bioavailability 6 56.40 Quite High
Kinase C 4 24.56 Low Low
ischemia 30 5.00 Very Low Very Low Very Low
cva 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 27 100.00 Very High Very High Very High
Neutrophil Disorders 9 100.00 Very High Very High Very High
Infection 6 100.00 Very High Very High Very High
Granuloma 1 100.00 Very High Very High Very High
Autoimmune Disease 11 99.76 Very High Very High Very High
INFLAMMATION 75 97.88 Very High Very High Very High
Vasculitis 9 91.00 High High
Disease 71 90.04 High High
Arthritis 69 89.48 High High
Stress 33 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
collared arteries by suppressing the NADPH-oxidase activity rather than
NADPH-oxidase Binding (activity) of
1) Confidence 0.32 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.51 Pain Relevance 0.03
Apocynin has been used as an efficient inhibitor of the complex NADPH-oxidase
NADPH-oxidase Binding (complex) of
2) Confidence 0.32 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.13 Pain Relevance 0
Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production.
NADPH-oxidase Binding (assembly) of
3) Confidence 0.32 Published 2008 Journal Mediators of Inflammation Section Abstract Doc Link PMC2593395 Disease Relevance 0.38 Pain Relevance 0.13
However, the transition of cytochrome b558 to an activated state appears to be a result of the binding of the S100 complex.
cytochrome b558 Binding (binding) of
4) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
As the genomic sequence assembly continues to evolve, CGD looks forward to providing the Candida research community with the latest DNA and protein sequence, and with the tools necessary to navigate and analyze this wealth of information.
CGD Spec (analyze) Binding (providing) of
5) Confidence 0.05 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1669745 Disease Relevance 0.06 Pain Relevance 0
CGD is caused by an inability of the NADPH oxidase to produce oxygen radicals and is characterized by recurrent infections, sterile granuloma but is also associated with autoimmune diseases [32,33].
CGD Binding (associated) of associated with autoimmune disease, granuloma, infection and neutrophil disorders
6) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2924308 Disease Relevance 1.71 Pain Relevance 0.13
They found a genetic association between RA and the NADPH-oxidase complex, thus supporting the previous findings from animal models.
NADPH-oxidase Binding (association) of associated with rheumatoid arthritis
7) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 1.51 Pain Relevance 0.48

General Comments

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