INT199875

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.77
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
granulocytes 2
plasma 1
monocytes 1
leukocytes 1
endothelial cells 1
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 36 97.44 Very High Very High Very High
Pain 12 96.64 Very High Very High Very High
Inflammatory response 21 96.20 Very High Very High Very High
Inflammation 91 95.88 Very High Very High Very High
chemokine 4 95.44 Very High Very High Very High
Tetrahydrobiopterin 4 59.60 Quite High
cytokine 10 53.24 Quite High
antagonist 13 51.28 Quite High
Inflammatory mediators 4 47.80 Quite Low
Bioavailability 6 20.60 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 38 97.82 Very High Very High Very High
Cv Unclassified Under Development 32 97.44 Very High Very High Very High
Pain 11 96.64 Very High Very High Very High
INFLAMMATION 114 95.88 Very High Very High Very High
Death 15 94.72 High High
Neointima 3 93.84 High High
Bronchopulmonary Dysplasia 15 93.52 High High
Stress 55 93.16 High High
Injury 45 91.28 High High
Hyperplasia 3 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another rationale of 7D5 colabeling is that the localization of Nox2 in granulocytes is relatively well explored [22], [23].
Localization (localization) of Nox2 in granulocytes
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
Subcellular colocalization of Hv1 and Nox2 was a general finding.
Localization (colocalization) of Nox2
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.06 Pain Relevance 0
In case of eosinophils, the strong colocalization with Nox2 suggests that Hv1 localizes to the plasma membrane and to the membrane of small granules [23].


Localization (colocalization) of Nox2 in plasma
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.05 Pain Relevance 0
Distribution of Hv1 and Nox2 was detected using confocal laser scanning microscopy.
Localization (Distribution) of Nox2
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
D) Do Hv1 and Nox2 colocalize in granulocytes?
Localization (colocalize) of Nox2 in granulocytes
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.14 Pain Relevance 0
NADPH-oxidase is implicated in vascular remodelling
Localization (implicated) of NADPH-oxidase
6) Confidence 0.65 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.62 Pain Relevance 0
Apocynin prevents the translocation of p47phox to Nox2 in leukocytes, monocytes,
Localization (translocation) of Nox2 in leukocytes
7) Confidence 0.65 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.35 Pain Relevance 0
Analysis of Hv1 and Nox2 colocalization was performed only in cells in which at least moderate labeling (two times above background) for both proteins could be detected.
Localization (colocalization) of Nox2
8) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.10 Pain Relevance 0.10
This result indicates that proteolytic degradation can spoil the detection of Hv1 also in immunofluorescence experiments, resulting in the underestimation of Hv1 and Nox2 colocalization.
Localization (colocalization) of Nox2
9) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.09 Pain Relevance 0
Apocynin prevents the translocation of p47phox to Nox2 in leukocytes, monocytes,
Localization (translocation) of Nox2 in monocytes
10) Confidence 0.22 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.35 Pain Relevance 0
Results of flow cytometry with these cells show that 20% of HT29 cells had undergone apoptosis which could not be rescued by oxidant inhibitors, e.g., diphenyleneiodonium chloride (DPI) and rotenone for NADPH oxidase and electron transport in complex I of mitochondria, respectively (data not shown), or iron chelation with 5 ?
Localization (transport) of NADPH oxidase associated with apoptosis
11) Confidence 0.12 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 1.19 Pain Relevance 0
Sequence visualization and retrieval at CGD
Localization (visualization) of CGD
12) Confidence 0.09 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1669745 Disease Relevance 0.16 Pain Relevance 0
The source of this superoxide is likely the NADPH oxidase that is co-localized with eNOS in subcellular compartments within endothelial cells [51].
Localization (localized) of NADPH oxidase in endothelial cells
13) Confidence 0.07 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.59 Pain Relevance 0.11
Furthermore, studies have shown that the effect of NADPH-oxidase mediated ROS release can be attenuated by angiotensin converting enzyme (ACE) inhibition.
Localization (release) of NADPH-oxidase
14) Confidence 0.02 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.78 Pain Relevance 0.21
Oxidative stress to the immature lung is a major contributing factor for the development of BPD.36 NADPH oxidase is responsible for superoxide anion production (O2-), which generates other ROS such as hydrogen peroxide, hydroxyl radical and hypochlorous acid.20 As the cytoplasmic subunits p47phox, p67phox, p40phox and Rac translocate to membrane-bound cytochrome upon activation of this multicomponent enzyme complex NADPH oxidase,37 membrane translocation of the p67phox can be served as an in vivo indicator of NADPH oxidase activation as shown in our previous study.38
Localization (translocation) of NADPH oxidase in lung associated with stress and bronchopulmonary dysplasia
15) Confidence 0.02 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.68 Pain Relevance 0.05
ROS are generated from various catalytic pathways mediated by enzymes which are differentially localized inside the cell, including NO synthases, enzymes of the respiratory chain, cytochrome P450 monoxygenases, xanthine oxidase, and NADPH oxidase.
Localization (localized) of NADPH oxidase in respiratory
16) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.62 Pain Relevance 0.15

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