INT19993

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 20.89
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 15
kidney 3
blood 1
sympathetic 1
brain 1
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
Clonidine 23 99.98 Very High Very High Very High
transdermal 9 99.78 Very High Very High Very High
antagonist 96 99.76 Very High Very High Very High
bradykinin 34 98.36 Very High Very High Very High
cytokine 13 97.80 Very High Very High Very High
substance P 11 97.76 Very High Very High Very High
Calcium channel 18 97.60 Very High Very High Very High
Potency 12 97.40 Very High Very High Very High
Bioavailability 28 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 18 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 4 100.00 Very High Very High Very High
Depression 2 100.00 Very High Very High Very High
Pressure And Volume Under Development 35 99.96 Very High Very High Very High
Bartter Syndrome 5 99.96 Very High Very High Very High
Targeted Disruption 33 99.80 Very High Very High Very High
Chronic Renal Failure 1024 99.64 Very High Very High Very High
Renal Disease 390 99.50 Very High Very High Very High
Hypertension 91 99.14 Very High Very High Very High
Myocardial Infarction 209 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, nonselective beta-blocking drugs possessing both beta 1- and beta 2-(vascular) blocking activity were found to be most effective in blocking plasma renin activity on oral administration.
Negative_regulation (blocking) of renin in plasma
1) Confidence 0.58 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6171684 Disease Relevance 0 Pain Relevance 0.13
Plasma renin activity is reduced; however, changes in plasma aldosterone level are not significant.
Negative_regulation (reduced) of Plasma renin in Plasma
2) Confidence 0.39 Published 1983 Journal Pharmacotherapy Section Abstract Doc Link 6344036 Disease Relevance 0.25 Pain Relevance 0.23
Transdermal clonidine reduced plasma renin activity and urinary aldosterone excretion to the same extent as that reported for oral clonidine.
Negative_regulation (reduced) of plasma renin in plasma associated with transdermal and clonidine
3) Confidence 0.37 Published 1984 Journal Am. Heart J. Section Abstract Doc Link 6375331 Disease Relevance 0.09 Pain Relevance 0.82
All patients had suffered from hypertension with U waves in ECG and laboratory examinations revealed hypokalemia, hyperaldosteronemia and suppressed plasma renin activity.
Spec (examinations) Negative_regulation (suppressed) of plasma renin in plasma associated with hypertension and bartter syndrome
4) Confidence 0.37 Published 1986 Journal Hinyokika Kiyo Section Abstract Doc Link 3962810 Disease Relevance 0.93 Pain Relevance 0
A depression of plasma renin activity occurred in groups 3 and 4.
Negative_regulation (depression) of plasma renin in plasma associated with depression
5) Confidence 0.37 Published 1994 Journal Life Sci. Section Abstract Doc Link 8072387 Disease Relevance 0.90 Pain Relevance 0.18
Direct renin inhibition
Negative_regulation (inhibition) of renin
6) Confidence 0.32 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.53 Pain Relevance 0.16
Inhibition of renin activity has long been considered to be the logical step to interrupt the RAAS as it is the initial and rate limiting step in the formation of Ang I.
Negative_regulation (Inhibition) of renin
7) Confidence 0.32 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.52 Pain Relevance 0.15
In conscious hypertensive dogs LF 2.0254 (0.1 and 0.3 mg/kg per os) decreased blood pressure and concomitantly increased heart rate and plasma renin activity.
Negative_regulation (decreased) of plasma renin in plasma associated with heart rate under development, pressure volume 2 under development and hypertension
8) Confidence 0.31 Published 1990 Journal Fundam Clin Pharmacol Section Abstract Doc Link 2112508 Disease Relevance 0.30 Pain Relevance 0.20
Postoperatively, prompt normalization of blood pressure and decrease of plasma renin activity level were found.
Negative_regulation (decrease) of plasma renin in blood
9) Confidence 0.29 Published 1996 Journal Hinyokika Kiyo Section Abstract Doc Link 8693965 Disease Relevance 0.77 Pain Relevance 0.08
Unlike ACE inhibitors and ARBs, plasma renin activity is inhibited with aliskiren, and downstream components of the RAAS are suppressed.
Negative_regulation (inhibited) of plasma renin in plasma
10) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.04 Pain Relevance 0
Unlike ACE inhibitors, ARBs and other antihypertensive agents that cause an increase in plasma renin activity, aliskiren directly inhibits the catalytic activity of renin, thus reducing plasma renin activity and, in turn, the production of Ang II and aldosterone [63].
Negative_regulation (reducing) of plasma renin in plasma
11) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.24 Pain Relevance 0.11
Investigations showed hypokalaemia, suppressed serum renin and aldosterone.
Negative_regulation (suppressed) of serum renin associated with bartter syndrome
12) Confidence 0.27 Published 2006 Journal Singapore Med J Section Abstract Doc Link 16435060 Disease Relevance 0.45 Pain Relevance 0.09
These 3 studies demonstrate that aliskiren alone or combined with an ARB reduced albumin excretion in patients with diabetic nephropathy, suggesting that direct renin inhibition may be an additional treatment option in patients with type 2 diabetes and nephropathy.
Negative_regulation (inhibition) of renin associated with diabetes mellitus and renal disease
13) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.57 Pain Relevance 0
Renin is stored in secretory granules and is released in response to decreases in renal perfusion pressure, decreases in Cl- in the distal tubule fluid or increased sympathetic nerve stimulation via ?
Negative_regulation (decreases) of Renin in sympathetic
14) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.37 Pain Relevance 0
Recent developments in our understanding of RAAS biology and the use of direct renin inhibition are reviewed in the context of their potential impact on the prevention and management of chronic kidney disease.


Negative_regulation (inhibition) of renin in kidney associated with chronic renal failure
15) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Abstract Doc Link PMC2887501 Disease Relevance 1.07 Pain Relevance 0
Aliskiren, a direct renin inhibitor, offers a novel approach to inhibit the RAAS in chronic kidney disease.


Negative_regulation (inhibitor) of renin in kidney associated with chronic renal failure
16) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Abstract Doc Link PMC2887501 Disease Relevance 1.01 Pain Relevance 0
Aliskiren, alone or combined with hydrochlorothiazide or valsartan, is the first FDA-approved, orally active direct renin inhibitor, a new class of compounds designed to inhibit the RAAS.
Negative_regulation (inhibitor) of renin
17) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.40 Pain Relevance 0.16
Unlike ACE inhibitors, ARBs and other antihypertensive agents that cause an increase in plasma renin activity, aliskiren directly inhibits the catalytic activity of renin, thus reducing plasma renin activity and, in turn, the production of Ang II and aldosterone [63].
Negative_regulation (inhibits) of renin in plasma
18) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.30 Pain Relevance 0.13
Direct renin inhibition with aliskiren represents a novel and potentially more effective way to inhibit the RAAS.
Negative_regulation (inhibition) of renin
19) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.07 Pain Relevance 0
The focus of this review is to discuss recent developments in RAAS biology of potential clinical relevance to chronic kidney disease and the potential impact of direct renin inhibition on the prevention and management of chronic kidney disease.


Negative_regulation (inhibition) of renin in kidney associated with chronic renal failure
20) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.62 Pain Relevance 0

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