INT19995

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 8.11
Pain Relevance 5.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Prph)
Anatomy Link Frequency
neurons 8
peripheral nerves 2
skin 2
nociceptor 2
filaments 1
Prph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 96 100.00 Very High Very High Very High
dorsal root ganglion 325 99.82 Very High Very High Very High
Peripheral nerve injury 61 99.68 Very High Very High Very High
qutenza 74 98.72 Very High Very High Very High
IPN 4 97.68 Very High Very High Very High
Calcitonin gene-related peptide 40 97.56 Very High Very High Very High
unmyelinated 2 97.28 Very High Very High Very High
c fibre 2 96.76 Very High Very High Very High
adenocard 13 95.40 Very High Very High Very High
Mechanosensation 30 92.48 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 332 99.82 Very High Very High Very High
Stress 25 99.76 Very High Very High Very High
Nervous System Injury 113 99.68 Very High Very High Very High
Nociception 72 99.48 Very High Very High Very High
Injury 119 98.28 Very High Very High Very High
Inflammatory Pain 4 97.68 Very High Very High Very High
INFLAMMATION 206 88.12 High High
Body Weight 3 88.08 High High
Pain 152 81.60 Quite High
Aging 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the levels of peripherin, NGF isoforms and TrkA in skin, peripheral nerves and DRG, respectively, were not significantly reduced in aged rats.
Gene_expression (levels) of peripherin in peripheral nerves
1) Confidence 0.75 Published 2010 Journal Neurobiol. Aging Section Abstract Doc Link 18499304 Disease Relevance 0.31 Pain Relevance 0
However, the levels of peripherin, NGF isoforms and TrkA in skin, peripheral nerves and DRG, respectively, were not significantly reduced in aged rats.
Gene_expression (isoforms) of peripherin in peripheral nerves
2) Confidence 0.65 Published 2010 Journal Neurobiol. Aging Section Abstract Doc Link 18499304 Disease Relevance 0.31 Pain Relevance 0
Immunocytochemistry demonstrated that activated ERK was present in neurons containing peripherin, a marker of nociceptive neurons.
Gene_expression (present) of peripherin in neurons associated with nociception
3) Confidence 0.32 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396664 Disease Relevance 0.35 Pain Relevance 0.54
Cryosections of excised DRGs were stained for macrophages (ED1 marker) and T cells (T-cell receptor marker) [15], and for damaged neurons expressing activating transcription factor 3 (ATF3) in subpopulations of medium- to large-sized DRG neurons expressing neurofilament-200 (NF-200) [16] and small-sized DRG neurons expressing peripherin, a marker found predominantly in small sensory ganglion cells with unmyelinated C-fiber axons [17].
Gene_expression (expressing) of peripherin in T-cell associated with ganglion cysts, c fibre, dorsal root ganglion and unmyelinated
4) Confidence 0.28 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022745 Disease Relevance 0.58 Pain Relevance 0.55
However, the levels of peripherin, NGF isoforms and TrkA in skin, peripheral nerves and DRG, respectively, were not significantly reduced in aged rats.
Gene_expression (levels) of peripherin in skin
5) Confidence 0.26 Published 2010 Journal Neurobiol. Aging Section Abstract Doc Link 18499304 Disease Relevance 0.31 Pain Relevance 0
Neuronal intermediate filaments in rat dorsal root ganglia: differential distribution of peripherin and neurofilament protein immunoreactivity and effect of capsaicin.
Gene_expression (distribution) of peripherin and neurofilament protein in filaments associated with qutenza
6) Confidence 0.25 Published 1990 Journal Brain Res. Section Title Doc Link 2113415 Disease Relevance 0 Pain Relevance 0.39
Although the percentage of PAP-II-positive neurons expressing peripherin was slightly decreased (from 54.6 ± 10.3% to 48.7 ± 8.7%), co-expression of PAP-II and peripherin was still present in small DRG neurons (Fig. 7A and 7B).
Gene_expression (expression) of peripherin in neurons associated with dorsal root ganglion
7) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.36 Pain Relevance 0.85
Interestingly, there were no differences between preconditioned and unconditioned rats in the ipsilateral DRGs; the preconditioning injury did not affect the percentage of large NF-200 positive neurons (Figure 2A) and small peripherin positive neurons (Figure 2B) expressing ATF3, or the density of macrophages (Figure 2C) and number of infiltrating T cells (Figure 2D) following the PSNL.
Gene_expression (expressing) of peripherin in neurons associated with injury
8) Confidence 0.24 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022745 Disease Relevance 0.36 Pain Relevance 0.19
However, the levels of peripherin, NGF isoforms and TrkA in skin, peripheral nerves and DRG, respectively, were not significantly reduced in aged rats.
Gene_expression (isoforms) of peripherin in skin
9) Confidence 0.22 Published 2010 Journal Neurobiol. Aging Section Abstract Doc Link 18499304 Disease Relevance 0.31 Pain Relevance 0
The present study shows that peripheral nerve injury induces PAP-II expression in peripherin-containing small DRG neurons which mostly expressed neither CGRP nor IB4, followed by a shift to NPY-containing large DRG neurons 14 days after peripheral axotomy.
Gene_expression (expression) of peripherin in neurons associated with dorsal root ganglion, nervous system injury, calcitonin gene-related peptide and peripheral nerve injury
10) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.88 Pain Relevance 0.96
Although the percentage of PAP-II-positive neurons expressing peripherin was slightly decreased (from 54.6 ± 10.3% to 48.7 ± 8.7%), co-expression of PAP-II and peripherin was still present in small DRG neurons (Fig. 7A and 7B).
Gene_expression (expressing) of peripherin in neurons associated with dorsal root ganglion
11) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.46 Pain Relevance 0.88
We found that small diameter sensory neurons that express peripherin represented the major class of NMB-1 binding neurons (Fig 6a–c).
Gene_expression (express) of peripherin in neurons
12) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.07 Pain Relevance 0.12
To double label neurons for biotinylated NMB-1 binding and peripherin immunoreactivity, fixed cells were stained using a mouse anti-peripherin antibody (diluted 1?
Gene_expression (antibody) of peripherin in neurons
13) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0.06
We found that biotinylated NMB-1 selectively bound to peripherin-containing DRG neurons, most of which are nociceptors.
Gene_expression (neurons) of peripherin-containing in nociceptors associated with nociceptor
14) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0 Pain Relevance 0.43
Nearly all peripherin-positive neurons bound biotinylated NMB-1 and almost all NMB-1-positive cells showed peripherin immunoreactivity.
Gene_expression (showed) of peripherin in neurons
15) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.09 Pain Relevance 0.03
Peptide-sensitive currents were associated with nociceptive neurons and neurons that expressed the nociceptor marker peripherin showed selective staining with a biotinylated form of the peptide.
Gene_expression (expressed) of peripherin in nociceptor associated with nociception and nociceptor
16) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.18 Pain Relevance 0.40
First pass stress perfusion (PERF) (SSFP, TE/TR/FA 2.7/1.4/50°, 1 saturation prepulse per slice, 3 short axis slices/heart beat) was begun after 3 minutes of i.v. adenosine infusion (140 ?
Gene_expression (/) of PERF in heart associated with stress and adenocard
17) Confidence 0.04 Published 2008 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2575198 Disease Relevance 0.54 Pain Relevance 0.13

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