INT199975

Context Info Confidence 0.05 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.11 Pain Relevance 0

nucleoplasm (ESR1, PGR) enzyme binding (ESR1, PGR) DNA binding (ESR1, PGR) cytoplasm (ESR1, PGR) signal transduction (ESR1, PGR) nucleus (ESR1, PGR)

ESR1 (Homo sapiens) PGR (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 18 32.56 antagonist 3 5.00 agonist 1 5.00 pain pelvic 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Hyperplasia 1 53.32 Hypertrophy 1 52.68 Endometriosis (extended) 18 32.56 Polycystic Ovary Syndrome 9 27.84 Reprotox - General 3 6 21.60 Endometrial Cancer 1 5.00 Breast Cancer 1 5.00 Disease 1 5.00 Hypersensitivity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the first, estrogen works alone to stimulate ER-alpha and PR isoforms and to increase expression of a host of genes necessary for cell division and tissue growth.

estrogen Positive_regulation (stimulate) of PR

1) Confidence 0.05 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.11 Pain Relevance 0

General Comments

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