INT199977

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

nucleoplasm (ESR1, JUN) DNA binding (ESR1, JUN) nucleus (ESR1, JUN) transcription factor binding (ESR1, JUN) nuclear chromosome (JUN) aging (JUN)

ESR1 (Homo sapiens) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 43.44 endometriosis 18 9.44 agonist 1 5.00 pain pelvic 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Hypertrophy 1 90.32 Hyperplasia 1 89.04 Endometriosis (extended) 18 9.44 Polycystic Ovary Syndrome 9 5.00 Reprotox - General 3 6 5.00 Endometrial Cancer 1 5.00 Breast Cancer 1 5.00 Disease 1 5.00 Hypersensitivity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

During the proliferative phase, estrogen stimulates a large number of genes including c-fos and c-jun, cell cycle proteins and the estrogen receptor itself [30,31].

estrogen Positive_regulation (stimulates) of c-jun

1) Confidence 0.03 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.