INT199993

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Context Info
Confidence 0.79
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MAP2) cytoskeleton (MAP2) intracellular (MAP2)
cytoplasm (MAP2)
Anatomy Link Frequency
neurite 3
MAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 8 93.76 High High
sodium channel 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Malformation 16 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dephosphorylated MAP2 acts as a cross-linker between microtubules, stabilising the bundles and promoting microtubule assembly.
Phosphorylation (Dephosphorylated) of MAP2
1) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
This includes submembrane calcium hotspots in the cell body driving neurite initiation [14,15], submembrane calcium hotspots at the tip of a growth cone influencing filopodium initiation and ultimately growth direction [32], and changes in calcium concentration at a neurite tip altering the phosphorylation state of MAP2 and ultimately the balance between elongation and branching [55,56].
Phosphorylation (phosphorylation) of MAP2 in neurite
2) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0.05
The elongation and branching rates are given by:

where cl is the concentration of free tubulin at a neurite tip, Bl is the concentration of dephosphorylated and microtubule-bound MAP2, Pl is the concentration of phosphorylated MAP2 and Pb, is the probability of branching.

Phosphorylation (phosphorylated) of MAP2 in neurite
3) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
(De)phosphorylation of MAP2 is a Michaelis-Menten function of the calcium concentration, with small changes in calcium possibly resulting in a large shift in the balance between phosphorylated and dephosphorylated MAP2.
Phosphorylation (phosphorylated) of MAP2
4) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
(De)phosphorylation of MAP2 is a Michaelis-Menten function of the calcium concentration, with small changes in calcium possibly resulting in a large shift in the balance between phosphorylated and dephosphorylated MAP2.
Phosphorylation (phosphorylation) of MAP2
5) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
Complex models of neurite elongation and branching [55,56] predict variations in calcium concentration over time at neurite tips that could alter the balance between elongation and branching through effecting the phosphorylation state of MAP2.
Phosphorylation (phosphorylation) of MAP2 in neurite
6) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
(De)phosphorylation of MAP2 is a Michaelis-Menten function of the calcium concentration, with small changes in calcium possibly resulting in a large shift in the balance between phosphorylated and dephosphorylated MAP2.
Phosphorylation (dephosphorylated) of MAP2
7) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
Phosphorylated MAP2, on the other hand, loses its cross-linking ability and destabilises the microtubule bundles, thus increasing the likelihood of a bifurcation event.
Phosphorylation (Phosphorylated) of MAP2
8) Confidence 0.79 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0

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