INT20003

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Context Info
Confidence 0.71
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 125
Total Number 126
Disease Relevance 8.78
Pain Relevance 23.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
neurons 51
spikes 9
brain 5
SCN 5
shell 3
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 3298 100.00 Very High Very High Very High
Neuropeptide 627 100.00 Very High Very High Very High
Raphe 531 100.00 Very High Very High Very High
Nav1.2 37 100.00 Very High Very High Very High
Spinal cord 22 100.00 Very High Very High Very High
Somatostatin 578 99.98 Very High Very High Very High
gABA 1082 99.96 Very High Very High Very High
Action potential 805 99.74 Very High Very High Very High
GABA receptor 102 99.46 Very High Very High Very High
amygdala 10 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 100.00 Very High Very High Very High
Aging 139 99.76 Very High Very High Very High
Neuroleptic Malignant Syndrome 170 99.40 Very High Very High Very High
Injury 37 99.16 Very High Very High Very High
Leukemia 1 99.16 Very High Very High Very High
Body Weight 17 98.84 Very High Very High Very High
Diabetic Nephropathy 2 98.72 Very High Very High Very High
Aids-related Complex 52 98.52 Very High Very High Very High
Weight Loss 7 98.24 Very High Very High Very High
Generalized Anxiety Disorder 68 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show for the first time that Scn2a1, Scn3a, Scn5a, and Scn8a, as well as all VGSC beta subunits are expressed in the longitudinal smooth muscle layer of the rat myometrium.
Gene_expression (expressed) of Scn2a1 in myometrium
1) Confidence 0.71 Published 2007 Journal Biol. Reprod. Section Abstract Doc Link 17671266 Disease Relevance 0 Pain Relevance 0.37
Use of intact aortic rings or aortic strips produced identical results in response to SCN-KRB and the experimental maneuvers.
Gene_expression (produced) of SCN-KRB
2) Confidence 0.68 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2114295 Disease Relevance 0 Pain Relevance 0.08
Using end-point and real-time quantitative RT-PCR, we detected the presence of the VGSC alpha subunits Scn2a1, Scn3a, Scn5a, and Scn8a in the cDNA from longitudinal muscle.
Gene_expression (presence) of Scn2a1 in longitudinal muscle
3) Confidence 0.61 Published 2007 Journal Biol. Reprod. Section Abstract Doc Link 17671266 Disease Relevance 0 Pain Relevance 0.38
Long-term recordings of the discharge rate of SCN neurons revealed that orexin A is able to induce phase shifts in cultured SCN neurons as well as in organotypic brain slices.
Gene_expression (neurons) of SCN in brain
4) Confidence 0.58 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19519637 Disease Relevance 0 Pain Relevance 0.14
Long-term recordings of the discharge rate of SCN neurons revealed that orexin A is able to induce phase shifts in cultured SCN neurons as well as in organotypic brain slices.
Gene_expression (neurons) of SCN in brain
5) Confidence 0.58 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19519637 Disease Relevance 0 Pain Relevance 0.15
We used the two-microelectrode voltage-clamp technique to test the effects of DM, DF, AM, CM and HM on Na(+) currents (I(Na)) in Xenopus oocytes expressing cRNAs encoding rat brain Nav1.2 alpha and beta1 or beta2 subunits.
Gene_expression (expressing) of Nav1.2 in brain associated with nav1.2
6) Confidence 0.58 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17346698 Disease Relevance 0 Pain Relevance 0.18
In the same study, melatonin rhythms were shown to be phase aligned with the SCN clock gene expression and were not affected by the free-running locomotor rhythms induced by drug treatment [21].
Gene_expression (expression) of SCN
7) Confidence 0.56 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.47 Pain Relevance 0.17
SS producing neurons of the SCN are located in both the core and shell portions [237] and form a distinct peptidergic neuronal group.
Gene_expression (producing) of SCN in neurons associated with somatostatin
8) Confidence 0.55 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.46
Aging effects of SCN neuropeptide expression, like the circadian profile of peptide expression, may be species specific as far as the SCN is concerned.
Gene_expression (expression) of SCN associated with aging and neuropeptide
9) Confidence 0.55 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.16 Pain Relevance 0.73
SCN is produced by the application of a cryoprobe to the common sciatic nerve using a freeze-thaw-freeze cycle.
Gene_expression (produced) of SCN in sciatic nerve associated with sciatic nerve
10) Confidence 0.51 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 7690198 Disease Relevance 0.69 Pain Relevance 0.48
Nitric oxide production in the SCN has been linked to N-methyl D-aspartate (NMDA)-induced cyclic guanosine monophospahate (cGMP) production, and administration of cGMP produces phase shifts of circadian rhythms in vitro [62].
Gene_expression (production) of SCN
11) Confidence 0.48 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.06 Pain Relevance 0.42
It is estimated that 9%–24 % of SCN neurons express VIP [26,158].
Gene_expression (express) of SCN in neurons
12) Confidence 0.48 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.14
An increase in discharge rate of SCN neurons was observed on NT application [90].
Gene_expression (neurons) of SCN in neurons
13) Confidence 0.48 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.38
The receptor for VIP, VPAC2,also known as Vipr2, is expressed in about 60% of the SCN neurons, which respond to VIP with changes in firing rate [164,165].
Gene_expression (neurons) of SCN in neurons
14) Confidence 0.48 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.06
VIP, a gut polypeptide, has been identified as one of the main neurotransmitters of SCN neurons and participates in SCN function.
Gene_expression (neurons) of SCN in neurons associated with neurotransmitter
15) Confidence 0.48 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.17
A recent addition to the ever increasing list of neurotransmitters of the SCN is neuromedin S (NMS), a 36 amino acid neuropeptide.
Gene_expression (is) of SCN associated with neurotransmitter, neuroleptic malignant syndrome and neuropeptide
16) Confidence 0.48 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.33 Pain Relevance 0.41
Most notably, the loading of fluo-4 through the patching micro-pipette to the cell initially decreased both the AP firing rate and the level of resting membrane potential (Fig. 4) of SCN neurons.
Gene_expression (neurons) of SCN in neurons associated with action potential
17) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.32
Correlation between SCN-AVP expression and circadian organization of locomotor behaviour has been shown across species including rats [198] and hamsters[199].
Gene_expression (expression) of SCN
18) Confidence 0.43 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0
In addition to the SCN, PVN and IML are important brain structures controlling melatonin production.
Gene_expression (production) of SCN in brain structures associated with spinal cord
19) Confidence 0.43 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.93 Pain Relevance 0.31
The shell portion of the SCN, which is likely to be involved in the regulation of overt rhythms, projects within the SCN through SS fibres [239].
Gene_expression (projects) of SCN in shell associated with somatostatin
20) Confidence 0.42 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.07 Pain Relevance 0.58

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