INT200039

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 5.89
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ndn) nucleus (Ndn) DNA binding (Ndn)
cytoplasm (Ndn)
Anatomy Link Frequency
neurons 3
neuronal 2
embryos 2
sensory neurons 2
neurite 1
Ndn (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 24 100.00 Very High Very High Very High
Spinal cord 60 71.12 Quite High
Trk A 12 64.28 Quite High
Pain threshold 24 59.40 Quite High
lumbar region 36 44.88 Quite Low
Sciatic nerve 36 5.00 Very Low Very Low Very Low
Pain 24 5.00 Very Low Very Low Very Low
Eae 24 5.00 Very Low Very Low Very Low
tail-flick 12 5.00 Very Low Very Low Very Low
hyperexcitability 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 24 99.28 Very High Very High Very High
Targeted Disruption 48 98.88 Very High Very High Very High
Necrosis 12 98.60 Very High Very High Very High
Apoptosis 300 98.08 Very High Very High Very High
Nociception 180 97.60 Very High Very High Very High
Fasciculation 24 96.52 Very High Very High Very High
Death 276 93.56 High High
Neurodegenerative Disease 48 91.56 High High
Respiratory Distress 12 88.84 High High
Cognitive Disorder 24 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, recent data [37] suggest that Necdin promotes GABAergic differentiation; thus, a lack of GABAergic neurons in Ndn KO might lead a lack of neuronal inhibition.


Negative_regulation (lack) of Ndn KO in GABAergic neurons associated with gabaergic
1) Confidence 0.41 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.52 Pain Relevance 0.16
First, we explore the sensory-motor behaviour and reveal sensory deficits that might result from Necdin deficiency.
Negative_regulation (deficiency) of Necdin
2) Confidence 0.41 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.68 Pain Relevance 0
Finally, subtle morphological abnormalities were also reported suggesting that Necdin deficiency results in aberrant neuronal migration and affects axonal extension, arborization and fasciculation during development [13,23].
Negative_regulation (deficiency) of Necdin in neuronal associated with fasciculation and congenital anomalies
3) Confidence 0.41 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 1.14 Pain Relevance 0
We observe a significative loss of TrkA and TrkC sensory neurons in Ndn KO compared to wild type; this loss is achieved at E13.5 dpc and remains at P0.
Negative_regulation (loss) of Ndn KO in sensory neurons
4) Confidence 0.41 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.69 Pain Relevance 0
Indeed, a role of Necdin in neurite outgrowth depending on NGF might explain this discrepancy: a deficiency in axonal outgrowth would then lead to an alteration of neuronal differentiation and an additional loss of TrkA cell death, in later embryogenesis stages.
Negative_regulation (role) of Necdin in neurite associated with nociception and death
5) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.67 Pain Relevance 0.03
These data indicate that the abrogation of Necdin results in a partial loss of sensory neurons expressing TrkA and TrkC receptors.
Negative_regulation (abrogation) of Necdin in sensory neurons
6) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.29 Pain Relevance 0
The abrogation of Necdin does not disturb the axonal growth in early stages of neuronal differentiation
Negative_regulation (abrogation) of Necdin in neuronal
7) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.43 Pain Relevance 0.04
The abrogation of Necdin results in a relatively selective loss of neurons in DRGs: TrkA and TrkC cell populations are reduced but not TrkB population.
Negative_regulation (abrogation) of Necdin in neurons associated with nociception
8) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.50 Pain Relevance 0
Colabelling results showed that p75NTR is expressed only in a subset of sensory neurons (Islet1/2-positive), in a subpopulation of Necdin expressing neurons and more particularly in 40% of proprioceptive (TrkC) neurons (Runx3-positive).
Negative_regulation (subpopulation) of Necdin in neurons
9) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.23 Pain Relevance 0
Because Necdin is an imprinted gene, paternally expressed only, we crossed heterozygote males (+ m/- p) with wild type C57BL/6J females to produce experimental embryos; thus, in the generated litters, half the embryos were control and half were Necdin deficient.
Negative_regulation (deficient) of Necdin in embryos
10) Confidence 0.35 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.16 Pain Relevance 0.07
Unexpectedly, Necdin loss of function has no effect on p75NTR expressing neurons suggesting no direct genetic interaction between Necdin and P75NTR in this context.
Negative_regulation (loss) of Necdin in neurons
11) Confidence 0.35 Published 2006 Journal BMC Dev Biol Section Abstract Doc Link PMC1687209 Disease Relevance 0.57 Pain Relevance 0
However,, the pool of lumbar DRGs revealed a significant reduction of 26.2% in the density of Trka-expressing cells (WT: 2258 (1999, 2530), n = 5; Ndn KO: 1714 (1450, 1811), n = 5; *p < 0.05) (Fig. 2D,G,J) and a reduction of 37.8% in Trkc-positive neurons (WT: 292 (277, 321), n = 5; Ndn KO: 188 (157, 223), n = 5; *p < 0.05) (Fig. 2F,I,J)) in the mutant embryos.
Negative_regulation (reduction) of Ndn KO in embryos
12) Confidence 0.35 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox