INT200045

Context Info Confidence 0.17 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.43

Anatomy Link Frequency astrocyte 2 L1cam (Mus musculus)

Pain Link Frequency Relevance Heat imagery 32 85.12 Pain threshold 2 82.00 withdrawal 1 77.48 Pain 2 75.16 hyperexcitability 1 71.44 Somatosensory cortex 8 64.00 primary somatosensory cortex 1 46.80 Action potential 9 43.88 Spinal cord 5 36.24 Neurotransmitter 10 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 2 89.56 Pain 4 82.00 Frailty 1 73.28 Anxiety Disorder 3 5.64 Apoptosis 25 5.00 Death 23 5.00 Nociception 20 5.00 Syndrome 7 5.00 Neurodegenerative Disease 4 5.00 Targeted Disruption 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

At P0, comparing the volume of the first lumbar (L1) DRG between Ndn KO and wild type mice (WT), we observed a 37% reduction of the mutant L1 DRG volume (WT: 32 105 ?

Negative_regulation (reduction) of Localization (volume) of L1

1) Confidence 0.17 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.32 Pain Relevance 0.23

These differences reflect the cytoarchitectural difference of L1 and L2/3, as indicated by immunohistochemical staining of a fixed cortical slice against the astrocyte marker S100?

Negative_regulation (reflect) of Localization (difference) of L1 in astrocyte

2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0 Pain Relevance 0.20

General Comments

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