INT200047

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 17
Disease Relevance 10.78
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
neurons 12
brain 4
hippocampus 2
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 750 99.38 Very High Very High Very High
Hippocampus 215 99.36 Very High Very High Very High
depression 365 97.76 Very High Very High Very High
nociceptor 321 92.48 High High
induced neuropathy 1 91.28 High High
intrathecal 2 89.68 High High
Neurotransmitter 10 89.60 High High
Eae 22 88.08 High High
Nerve growth factor 30 84.40 Quite High
Pain 31 80.80 Quite High
Disease Link Frequency Relevance Heat
Repression 80 100.00 Very High Very High Very High
Congenital Anomalies 47 100.00 Very High Very High Very High
Suicidal Behaviour 615 99.88 Very High Very High Very High
Ganglion Cysts 853 99.38 Very High Very High Very High
Nociception 58 99.38 Very High Very High Very High
Targeted Disruption 470 98.76 Very High Very High Very High
Depression 475 97.76 Very High Very High Very High
Neuropathic Pain 7 90.64 High High
Neurodegenerative Disease 44 86.32 High High
Anxiety Disorder 8 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found similar changes in PFC and hippocampus of teenaged suicide subjects.184 Our finding of decreased full-length TrkB expression in the suicide brain specimen may have serious implications.
Negative_regulation (decreased) of Gene_expression (expression) of TrkB in brain associated with suicidal behaviour and hippocampus
1) Confidence 0.56 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.96 Pain Relevance 0.09
We found that the expression of full-length TrkB was significantly decreased in the PFC and hippocampus of suicide subjects compared with nonpsychiatric healthy controls.
Negative_regulation (decreased) of Gene_expression (expression) of TrkB in hippocampus associated with suicidal behaviour and hippocampus
2) Confidence 0.56 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.19 Pain Relevance 0.09
Runx3 repression of TrkB expression appears to be mediated by direct binding of Runx3 to the Ntrk2 locus [44].
Negative_regulation (repression) of Gene_expression (expression) of TrkB associated with repression
3) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.20
We have shown that neurons from a mouse model of neurodegeneration over-express trkB.T1, resulting in a significant increase in resting intracellular calcium; reducing trkB.T1 expression in those neurons reduced intracellular calcium to wildtype levels [23].
Negative_regulation (reducing) of Gene_expression (expression) of trkB in neurons
4) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.47 Pain Relevance 0.41
These results suggested a reduction in TrkB.T1 expression in suicide subjects, which was associated with the epigenetic modification of the TrkB.T1 promoter region.


Negative_regulation (reduction) of Gene_expression (expression) of TrkB associated with suicidal behaviour
5) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.50 Pain Relevance 0.04
The decrease in TrkB expression was specific to the T1 splice variant.
Negative_regulation (decrease) of Gene_expression (expression) of TrkB
6) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.50 Pain Relevance 0.03
Many postmortem brain studies in patients who complete suicide and in those with suicidal ideation or attempted suicide show decreased BDNF expression and abnormalities in its cognate TrkB/TrkB.T1 receptor.
Negative_regulation (decreased) of Gene_expression (expression) of TrkB in brain associated with suicidal behaviour and congenital anomalies
7) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 2.14 Pain Relevance 0.36
The persistence of detectable TrkB expression at P0 was confirmed by in situ hybridization (Additional file 4).
Negative_regulation (persistence) of Gene_expression (expression) of TrkB
8) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 0.25
Brn3a-/- TG neurons also exhibit abnormal persistence of the co-expression of TrkA and TrkB, and subsequent loss of TrkA expression.
Negative_regulation (persistence) of Gene_expression (-) of TrkB in neurons associated with trigeminal ganglion
9) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.72 Pain Relevance 0.42
In Brn3a knockout TG the Runx factors are markedly downregulated, leading to a failure to repress TrkB expression in TrkA- and TrkC-expressing neurons.
Negative_regulation (failure) of Gene_expression (expression) of TrkB in neurons associated with targeted disruption and trigeminal ganglion
10) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.24
Brn3a-/- TG neurons also exhibit abnormal persistence of the co-expression of TrkA and TrkB, and subsequent loss of TrkA expression.
Negative_regulation (persistence) of Gene_expression (expression) of TrkB in neurons associated with trigeminal ganglion
11) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.72 Pain Relevance 0.42
In Brn3a knockout TG the Runx factors are markedly downregulated, leading to a failure to repress TrkB expression in TrkA- and TrkC-expressing neurons.
Negative_regulation (repress) of Gene_expression (expression) of TrkB in neurons associated with targeted disruption and trigeminal ganglion
12) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.24
This is then followed by loss of TrkC expression in all TrkB/C precursors by E13.5.


Negative_regulation (loss) of Gene_expression (expression) of TrkB
13) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.30 Pain Relevance 0.20
Together these data show that Brn3a creates a permissive condition for the expression of the Runx factors, which then repress TrkB expression and allow differentiation of the principal sensory subtypes.


Negative_regulation (repress) of Gene_expression (expression) of TrkB
14) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.39 Pain Relevance 0.28
However, ectopic expression of Runx1 in E12.5 DRG represses TrkB expression, promotes both TrkA and TrkC, and appears to be interchangeable with Runx3 in these effects [23].
Negative_regulation (represses) of Gene_expression (expression) of TrkB
15) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.33 Pain Relevance 0.39
Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.



Negative_regulation (repress) of Gene_expression (expression) of TrkB
16) Confidence 0.40 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.40 Pain Relevance 0.27
The abrogation of Necdin results in a relatively selective loss of neurons in DRGs: TrkA and TrkC cell populations are reduced but not TrkB population.
Neg (not) Negative_regulation (reduced) of Neg (not) Gene_expression (population) of TrkB in neurons associated with nociception
17) Confidence 0.38 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.52 Pain Relevance 0

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