INT200051

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 3.55
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
neurons 8
sensory neurons 2
embryos 2
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 450 99.58 Very High Very High Very High
nociceptor 192 94.84 High High
Spinal cord 32 91.92 High High
Trk A 4 71.84 Quite High
lumbar region 12 49.84 Quite Low
calcitonin gene related peptide 66 34.08 Quite Low
Acute pain 6 9.80 Low Low
Neuropeptide 24 5.00 Very Low Very Low Very Low
mu opioid receptor 24 5.00 Very Low Very Low Very Low
Pain 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 78 99.90 Very High Very High Very High
Targeted Disruption 274 99.60 Very High Very High Very High
Ganglion Cysts 514 99.58 Very High Very High Very High
Repression 42 90.16 High High
Neurodegenerative Disease 34 86.32 High High
Apoptosis 100 85.92 High High
Death 104 84.72 Quite High
Necrosis 4 74.84 Quite High
Pain 34 9.80 Low Low
Syndrome 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The abnormally persistent co-expression of TrkB and TrkC in the Brn3a-/- TG, and the subsequent loss of TrkC expression, are all consistent with effects mediated by Runx3.
Negative_regulation (loss) of Gene_expression (expression) of TrkC associated with trigeminal ganglion
1) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.72 Pain Relevance 0.47
This is then followed by loss of TrkC expression in all TrkB/C precursors by E13.5.


Negative_regulation (loss) of Gene_expression (expression) of TrkC
2) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.30 Pain Relevance 0.20
However, we have shown that the lack of Necdin leads to a loss of TrkC expressing cells that in turn could explain the absence or reduction of afferent projections.
Negative_regulation (loss) of Gene_expression (expressing) of TrkC
3) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.41 Pain Relevance 0.08
The abrogation of Necdin results in a relatively selective loss of neurons in DRGs: TrkA and TrkC cell populations are reduced but not TrkB population.
Neg (not) Negative_regulation (reduced) of Neg (not) Gene_expression (population) of TrkC in neurons associated with nociception
4) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.52 Pain Relevance 0
These data indicate that the abrogation of Necdin results in a partial loss of sensory neurons expressing TrkA and TrkC receptors.
Spec (partial) Negative_regulation (loss) of Gene_expression (expressing) of TrkC in sensory neurons
5) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.32 Pain Relevance 0
However,, the pool of lumbar DRGs revealed a significant reduction of 26.2% in the density of Trka-expressing cells (WT: 2258 (1999, 2530), n = 5; Ndn KO: 1714 (1450, 1811), n = 5; *p < 0.05) (Fig. 2D,G,J) and a reduction of 37.8% in Trkc-positive neurons (WT: 292 (277, 321), n = 5; Ndn KO: 188 (157, 223), n = 5; *p < 0.05) (Fig. 2F,I,J)) in the mutant embryos.
Negative_regulation (reduction) of Gene_expression (positive) of Trkc in embryos
6) Confidence 0.35 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0 Pain Relevance 0
In Runx3-/- embryos, TrkC expression is lost, coupled with an increase in TrkB+ neurons, while mis-expression of Runx3 promotes TrkC and represses TrkB [23,34].
Negative_regulation (lost) of Gene_expression (expression) of TrkC in neurons
7) Confidence 0.30 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.18
For example, TrkC+ DRG proprioceptors develop from TrkB+/TrkC+ precursors, a subset of which initiate expression of Runx3, followed by downregulation of TrkB and exclusive expression of TrkC in the mature neuron [23].
Negative_regulation (downregulation) of Gene_expression (expression) of TrkC in neuron
8) Confidence 0.30 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.17
Our results for stage-specific changes in neurotrophin expression are consistent with prior studies showing early loss of TrkC expression [11,18], abnormally increased expression of TrkB at E12.5 to E13.5, and late loss of TrkA [18].
Negative_regulation (loss) of Gene_expression (expression) of TrkC
9) Confidence 0.30 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.41 Pain Relevance 0.16
These changes are accompanied by expanded expression of TrkB in neurons that abnormally express multiple Trks, followed by the loss of TrkC and TrkA expression.
Negative_regulation (loss) of Gene_expression (expression) of TrkC in neurons
10) Confidence 0.29 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 0.33

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