INT200057

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ndn, Ngfr) nucleus (Ndn, Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) DNA binding (Ndn) cytosol (Ndn)
Anatomy Link Frequency
sensory neurons 1
neurons 1
Ndn (Mus musculus)
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
lumbar region 15 9.08 Low Low
Spinal cord 25 5.00 Very Low Very Low Very Low
Sciatic nerve 15 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Pain threshold 10 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
GABAergic 10 5.00 Very Low Very Low Very Low
tail-flick 5 5.00 Very Low Very Low Very Low
hyperexcitability 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 115 100.00 Very High Very High Very High
Apoptosis 125 96.48 Very High Very High Very High
Targeted Disruption 20 95.04 Very High Very High Very High
Neurodegenerative Disease 20 87.72 High High
Fasciculation 10 85.16 High High
Nociception 75 84.84 Quite High
Skin Cancer 5 65.72 Quite High
Embryonal Carcinoma 5 59.36 Quite High
Syndrome 35 56.60 Quite High
Disease 10 42.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, it has been shown that p75NTR interacts with Necdin [12] and a common signalling pathway involving Necdin and p75NTR has been proposed [15,22].
Necdin Binding (interacts) of p75NTR
1) Confidence 0.43 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.46 Pain Relevance 0
Necdin cytoplasmic interactors (FEZ1, BBS4, NEFA and Nuc which are both Ca2+ binding proteins), or nuclear interactors such as cell-cycle proteins (E2F1, E2F2, p53) and neurotrophic receptors (p75NTR, TrkA) have been characterized.
Necdin Binding (interactors) of p75NTR
2) Confidence 0.38 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.30 Pain Relevance 0
Unexpectedly, Necdin loss of function has no effect on p75NTR expressing neurons suggesting no direct genetic interaction between Necdin and P75NTR in this context.
Necdin Neg (no) Binding (interaction) of P75NTR in neurons
3) Confidence 0.37 Published 2006 Journal BMC Dev Biol Section Abstract Doc Link PMC1687209 Disease Relevance 0.49 Pain Relevance 0
These data suggest that there is no direct genetic interaction between p75NTR and Necdin to prevent the regulated cell death in post-mitotic developing sensory neurons.


Necdin Neg (no) Binding (interaction) of p75NTR in sensory neurons associated with death
4) Confidence 0.37 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.48 Pain Relevance 0
Interestingly, it is not only Necdin but also other members of the family such as NRAGE and MAGEH1 which interact with the death domain of the low affinity receptor to neurotrophin p75NTR [5,12,14,15].
Necdin Binding (interact) of low affinity receptor associated with death
5) Confidence 0.32 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.23 Pain Relevance 0

General Comments

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