INT200059

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gtf3a, Ndn) DNA binding (Gtf3a, Ndn) cytosol (Ndn)
RNA binding (Gtf3a) intracellular (Gtf3a) cytoplasm (Ndn)
Gtf3a (Mus musculus)
Ndn (Mus musculus)
Pain Link Frequency Relevance Heat
lumbar region 6 18.52 Low Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
tail-flick 2 5.00 Very Low Very Low Very Low
hyperexcitability 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 30 97.14 Very High Very High Very High
Apoptosis 50 93.84 High High
Neurodegenerative Disease 8 93.40 High High
Death 46 46.40 Quite Low
Syndrome 14 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that neurogenesis in developing DRGs is a dynamic process and the expression patterns of the different Trk proteins are also highly dynamic between E10.5 and E13.5, another interpretation is that the TrkA and TrkC populations present at E13.5 expressed a common receptor at an earlier stage of their development and required a common neurotrophic factor that could trigger Necdin function as a survival factor.
factor Positive_regulation (trigger) of Necdin associated with nociception and neurodegenerative disease
1) Confidence 0.06 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.44 Pain Relevance 0
Considering that neurogenesis in developing DRGs is a dynamic process and the expression patterns of the different Trk proteins are also highly dynamic between E10.5 and E13.5, another interpretation is that the TrkA and TrkC populations present at E13.5 expressed a common receptor at an earlier stage of their development and required a common neurotrophic factor that could trigger Necdin function as a survival factor.
factor Positive_regulation (trigger) of Necdin associated with nociception and neurodegenerative disease
2) Confidence 0.04 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.44 Pain Relevance 0

General Comments

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