INT20006
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The early identification of an important role of metallothionein in cadmium toxicology formed the basis for recent studies using biomarkers of susceptibility to development of Cd-related renal dysfunction such as gene expression of metallothionein in peripheral lymphocytes and autoantibodies against metallothionein in blood plasma. | |||||||||||||||
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Immunohistochemical expression of metallothionein in normal human colorectal mucosa, in adenomas and in adenocarcinomas and their associated metastases. | |||||||||||||||
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The immunohistochemical distribution pattern of metallothionein, a low molecular weight protein with strong affinity for divalent heavy metal ions, has been investigated in normal and neoplastic conditions of the large bowel. | |||||||||||||||
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of multiple members of the metallothionein gene family expression, which | |||||||||||||||
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Here cadmium induces the production of Metallothionein. | |||||||||||||||
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Metallothionein expression seems to protect endometrial cells against apoptosis. | |||||||||||||||
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The aim of the present study was to evaluate RCAS1 and metallothionein expression in human ovarian and scar endometriomas in relation to the presence of immune cells and their activity.
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Metallothionein, RCAS1, CD25, CD69, CD56, CD16, CD68 antigen expression was assessed by immunohistochemistry in ovarian and scar endometriomas tissue samples which were obtained from 33 patients. | |||||||||||||||
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Stronger Metallothionein expression was determined in scar endometriomas and in secretory endometrium than in ovarian endometriosis. | |||||||||||||||
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The alterations in RCAS1 and Metallothionein expression are accompanied by changes in CD25, CD56 and CD69 antigens expression on immune cells. | |||||||||||||||
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The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer. | |||||||||||||||
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Comparison of RCAS1 and metallothionein expression and the presence and activity of immune cells in human ovarian and abdominal wall endometriomas
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The expression of RCAS1 and metallothionein by endometrial cells may favor the persistence of these cells in ectopic localization both in scar following cesarean section and in ovarian endometriosis.
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The lowest metallothionein expression was revealed in ovarian endometriomas in comparison to scar endometriomas and to the control group. | |||||||||||||||
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The expression of RCAS1 and metallothionein by endometrial cells is important for the coexistence of activated immune cells together with endometrial cells during decidualization in secretory cycle phase. | |||||||||||||||
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The aim of the present study was to evaluate RCAS1 and metallothionein expression in ovarian and scar endometriomas in relation to immune cell presence and their activity.
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Mice injected with 4 mg/kg CdCl2 expressed a 2.5-fold increase in DNA synthesis in the pancreas, which Andrews et al. (1990) and Hellman (1986) interpreted as a sign of increased metallothionein synthesis. | |||||||||||||||
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In addition, the metallothionein downregulation was preceded by a downregulation of MTF1, the transcription factor regulating metallothionein expression, by the low curcumin concentration (Table 1). | |||||||||||||||
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Expression of metallothionein in colon tumors is associated with poor prognosis [46]. | |||||||||||||||
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However, both aspirin and sulindac increased expression of several metallothionein genes, which were downregulated by curcumin in our study [76]. | |||||||||||||||
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General Comments
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