INT20006

Context Info Confidence 0.68 First Reported 1986 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 27 Total Number 28 Disease Relevance 19.55 Pain Relevance 3.18

nucleus (MT1F) cytoplasm (MT1F)

Anatomy Link Frequency immune cells 5 plasma 2 colon 2 pancreas 1 bladder 1 MT1F (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 22 99.52 endometriosis 520 98.76 agonist 103 98.72 cINOD 26 97.60 Paracetamol 10 96.24 antagonist 69 95.12 cytokine 6 89.72 interstitial cystitis 1 84.00 Inflammation 29 75.92 anesthesia 1 70.16

Disease Link Frequency Relevance Heat Colon Cancer 215 99.84 Renal Disease 7 99.72 Endometriosis 900 99.56 Cyst 30 99.44 Cicatrix 470 99.36 Bladder Cancer 9 98.80 Adenoma 13 98.44 Apoptosis 616 98.24 Adenocarcinoma 12 97.80 Toxicity 69 97.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The early identification of an important role of metallothionein in cadmium toxicology formed the basis for recent studies using biomarkers of susceptibility to development of Cd-related renal dysfunction such as gene expression of metallothionein in peripheral lymphocytes and autoantibodies against metallothionein in blood plasma.

Gene_expression (expression) of metallothionein in plasma associated with renal disease

1) Confidence 0.68 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19341754 Disease Relevance 0.42 Pain Relevance 0.05

Immunohistochemical expression of metallothionein in normal human colorectal mucosa, in adenomas and in adenocarcinomas and their associated metastases.

Gene_expression (expression) of metallothionein associated with adenocarcinoma, adenoma and metastasis

2) Confidence 0.60 Published 1996 Journal Histopathology Section Title Doc Link 8910042 Disease Relevance 0.98 Pain Relevance 0.07

The immunohistochemical distribution pattern of metallothionein, a low molecular weight protein with strong affinity for divalent heavy metal ions, has been investigated in normal and neoplastic conditions of the large bowel.

Spec (investigated) Gene_expression (pattern) of metallothionein in bowel

3) Confidence 0.52 Published 1996 Journal Histopathology Section Abstract Doc Link 8910042 Disease Relevance 0.61 Pain Relevance 0

of multiple members of the metallothionein gene family expression, which

Gene_expression (expression) of metallothionein

4) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0.20

Here cadmium induces the production of Metallothionein.

Gene_expression (production) of Metallothionein

5) Confidence 0.31 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1578573 Disease Relevance 0.33 Pain Relevance 0

Metallothionein expression seems to protect endometrial cells against apoptosis.

Gene_expression (expression) of Metallothionein associated with apoptosis

6) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 0.75 Pain Relevance 0

The aim of the present study was to evaluate RCAS1 and metallothionein expression in human ovarian and scar endometriomas in relation to the presence of immune cells and their activity.

Gene_expression (expression) of metallothionein in immune cells associated with endometriosis and cicatrix

7) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 0.81 Pain Relevance 0

Metallothionein, RCAS1, CD25, CD69, CD56, CD16, CD68 antigen expression was assessed by immunohistochemistry in ovarian and scar endometriomas tissue samples which were obtained from 33 patients.

Gene_expression (expression) of Metallothionein associated with endometriosis and cicatrix

8) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.11 Pain Relevance 0

Stronger Metallothionein expression was determined in scar endometriomas and in secretory endometrium than in ovarian endometriosis.

Gene_expression (expression) of Metallothionein in endometrium associated with endometriosis and cicatrix

9) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.52 Pain Relevance 0.35

The alterations in RCAS1 and Metallothionein expression are accompanied by changes in CD25, CD56 and CD69 antigens expression on immune cells.

Gene_expression (expression) of Metallothionein in immune cells

10) Confidence 0.18 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.32 Pain Relevance 0.31

The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.

Gene_expression (expressed) of MT-1F in bladder associated with bladder cancer

11) Confidence 0.17 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.12 Pain Relevance 0.08

Comparison of RCAS1 and metallothionein expression and the presence and activity of immune cells in human ovarian and abdominal wall endometriomas Background

Gene_expression (expression) of metallothionein in immune cells associated with endometriosis

12) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Title Doc Link PMC1574328 Disease Relevance 0.71 Pain Relevance 0

The expression of RCAS1 and metallothionein by endometrial cells may favor the persistence of these cells in ectopic localization both in scar following cesarean section and in ovarian endometriosis.

Gene_expression (expression) of metallothionein associated with endometriosis and cicatrix

13) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.46 Pain Relevance 0.05

The lowest metallothionein expression was revealed in ovarian endometriomas in comparison to scar endometriomas and to the control group.

Gene_expression (expression) of metallothionein associated with endometriosis and cicatrix

14) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.42 Pain Relevance 0

The expression of RCAS1 and metallothionein by endometrial cells is important for the coexistence of activated immune cells together with endometrial cells during decidualization in secretory cycle phase.

Gene_expression (expression) of metallothionein in immune cells

15) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.26 Pain Relevance 0.18

The aim of the present study was to evaluate RCAS1 and metallothionein expression in ovarian and scar endometriomas in relation to immune cell presence and their activity.

Gene_expression (expression) of metallothionein in immune cell associated with endometriosis and cicatrix

16) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.18 Pain Relevance 0.17

Mice injected with 4 mg/kg CdCl2 expressed a 2.5-fold increase in DNA synthesis in the pancreas, which Andrews et al. (1990) and Hellman (1986) interpreted as a sign of increased metallothionein synthesis.

Gene_expression (synthesis) of metallothionein in pancreas

17) Confidence 0.15 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1332665 Disease Relevance 0.27 Pain Relevance 0

In addition, the metallothionein downregulation was preceded by a downregulation of MTF1, the transcription factor regulating metallothionein expression, by the low curcumin concentration (Table 1).

Gene_expression (expression) of metallothionein

18) Confidence 0.10 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.17 Pain Relevance 0

Expression of metallothionein in colon tumors is associated with poor prognosis [46].

Gene_expression (Expression) of metallothionein in colon associated with colon cancer

19) Confidence 0.09 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.26 Pain Relevance 0

However, both aspirin and sulindac increased expression of several metallothionein genes, which were downregulated by curcumin in our study [76].

Gene_expression (expression) of metallothionein associated with aspirin

20) Confidence 0.08 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.19 Pain Relevance 0.53

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