INT200072

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 1.00
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT)
nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)
Anatomy Link Frequency
muscle 1
APRT (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 32 100.00 Very High Very High Very High
rheumatoid arthritis 39 88.64 High High
adenocard 25 87.00 High High
Inflammation 10 76.52 Quite High
Pain 9 41.36 Quite Low
imagery 11 5.00 Very Low Very Low Very Low
Catecholamine 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Enkephalin 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acid Base Imbalance 21 99.14 Very High Very High Very High
Stress 23 93.76 High High
Rheumatoid Arthritis 40 88.64 High High
Acidosis 6 88.24 High High
Shock 4 76.92 Quite High
INFLAMMATION 10 76.52 Quite High
Hyperplasia 4 61.84 Quite High
Malignant Neoplastic Disease 8 52.80 Quite High
Disorders Of Creatine Metabolism 4 44.36 Quite Low
Pneumoconiosis 4 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among all displacement parameters measured, only F1Amp, E1Amp, RI and ERI exhibited statistically significant changes between normal subjects and patients (Fig. 4 and Table 2).
Gene_expression (exhibited) of Amp
1) Confidence 0.65 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693559 Disease Relevance 0.25 Pain Relevance 0.12
The third reaction, the AMP deaminase reaction, does not regenerate ATP.
Gene_expression (reaction) of AMP
2) Confidence 0.11 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0.14 Pain Relevance 0
The onset of metabolic acidosis activates AMP deaminase and therefore the production of AMP and eventually the production of ammonia (NH4+).
Gene_expression (production) of AMP associated with acid base imbalance
3) Confidence 0.09 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0.26 Pain Relevance 0
This near immediate activation of carbohydrate oxidation after the onset of exercise [37] is caused by the production of AMP, the increases in intramuscular free calcium and inorganic phosphate (both increase the rate of the phosphorylase reaction as calcium is an activator of phosphorylate and inorganic phosphate is a substrate), and the near spontaneous increase in blood glucose uptake into muscle caused by muscle contraction.
Gene_expression (production) of AMP in muscle
4) Confidence 0.09 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0 Pain Relevance 0
Apart from being a degradation product of ATP, AMP is known to activate the AMP-activated kinase (AMPK) system that is ubiquitously expressed in mammalian cells.
Gene_expression (expressed) of AMP
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.36 Pain Relevance 0.07
These metabolites participate in several biochemical pathways, such as polyamine biosynthesis, creatine biosynthesis, AMP biosynthesis, dopamine metabolism, lipid metabolism, redox reactions etc.
Gene_expression (biosynthesis) of AMP associated with dopamine
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.13
CEM cells, whereas the levels of creatine, arginine, dopamine, homovanillic acid and AMP were upregulated.
Gene_expression (levels) of AMP associated with dopamine
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.12
In HTLV1 transformed cells, choline, phosphocholine, spermine and glutathione, among others, were downregulated, whereas creatine, dopamine, arginine and AMP were present at higher levels.
Gene_expression (present) of AMP associated with dopamine
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.05
Solutions of adenine were produced by dissolving adenine powder (Sigma, 99% pure) in water (Easy Pure 18.3 M?
Gene_expression (produced) of adenine
9) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
There was no observable peak in reaction mixtures corresponding to the retention time of a 6-N-hydroxyaminopurine standard (also adenine + oxygen), which has been observed as peroxyl radical oxidation product of adenine [39].


Gene_expression (product) of adenine
10) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.04

General Comments

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