INT200090

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.67
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) aging (Ldlr)
plasma membrane (Ldlr) lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
neural 6
fat 2
Ldlr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 97.10 Very High Very High Very High
COX-2 inhibitor 3 65.52 Quite High
cINOD 12 62.92 Quite High
Inflammation 71 59.84 Quite High
antagonist 3 52.52 Quite High
Pyramidal cell 3 45.04 Quite Low
Hippocampus 21 43.04 Quite Low
potassium channel 6 36.80 Quite Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 42 99.62 Very High Very High Very High
Hyperlipidemia 21 98.76 Very High Very High Very High
Disease 117 96.30 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

3 91.52 High High
Gastrointestinal Disease 3 80.84 Quite High
Diarrhoea 4 79.60 Quite High
Metabolic Syndrome 3 79.12 Quite High
Premature Ventricular Beats 3 73.28 Quite High
Heart Rate Under Development 6 67.60 Quite High
Diabetes Mellitus 64 62.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is a acetylcholinesterase inhibitor similar to Galanthamine[9], a drug treating AD, and might be a low-molecular-weight neurotrophic drug to neurodegeneration disorder such as AD by potentiating the nerve growth factor (NGF)-induced differentiation in neural cells [10]; berberine is a novel cholesterol-lowering drug distinctly from statins by stabilizating the low density lipoprotein receptor (LDLR) mRNA to increase LDLR expression and inhibiting lipid synthesis[11,12].
Positive_regulation (increase) of Gene_expression (expression) of low density lipoprotein receptor in neural associated with nerve growth factor and disease
1) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.94 Pain Relevance 0.20
It is a acetylcholinesterase inhibitor similar to Galanthamine[9], a drug treating AD, and might be a low-molecular-weight neurotrophic drug to neurodegeneration disorder such as AD by potentiating the nerve growth factor (NGF)-induced differentiation in neural cells [10]; berberine is a novel cholesterol-lowering drug distinctly from statins by stabilizating the low density lipoprotein receptor (LDLR) mRNA to increase LDLR expression and inhibiting lipid synthesis[11,12].
Positive_regulation (increase) of Gene_expression (expression) of LDLR in neural associated with nerve growth factor and disease
2) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.93 Pain Relevance 0.20
It is a acetylcholinesterase inhibitor similar to Galanthamine[9], a drug treating AD, and might be a low-molecular-weight neurotrophic drug to neurodegeneration disorder such as AD by potentiating the nerve growth factor (NGF)-induced differentiation in neural cells [10]; berberine is a novel cholesterol-lowering drug distinctly from statins by stabilizating the low density lipoprotein receptor (LDLR) mRNA to increase LDLR expression and inhibiting lipid synthesis[11,12].
Positive_regulation (increase) of Gene_expression (expression) of LDLR in neural associated with nerve growth factor and disease
3) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.92 Pain Relevance 0.20
In conclusion, from the observation, the protective effect of the seeds of E. variegata on high fat induced hyperlipidemia may be attributed to a decrease in cholesterol synthesis, an increase in cholesterol excretion and expression of LDL receptor and subsequent catabolism.
Positive_regulation (increase) of Gene_expression (expression) of LDL receptor in fat associated with hyperlipidemia
4) Confidence 0.19 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.26 Pain Relevance 0
An increase of the cholesterol-HDL ratio, as well as increased levels of LDL-cholesterol were associated with both increased all-cause and cardiovascular mortality in the low age group.
Positive_regulation (increased) of Gene_expression (levels) of LDL-cholesterol associated with disorder of lipid metabolism
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795197 Disease Relevance 0.53 Pain Relevance 0

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