INT200103

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 3.41
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
bars 6
fibroblasts 4
keratinocytes 4
epithelial cells 2
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 69.40 Quite High
Pain 14 5.00 Very Low Very Low Very Low
cocaine 10 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Morphine 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 576 96.44 Very High Very High Very High
Frailty 2 93.96 High High
Toxicity 4 91.12 High High
Pancreatic Cancer 9 84.80 Quite High
Reprotox - General 1 19 75.52 Quite High
Benign Prostatic Hypertrophy 7 74.72 Quite High
Adenocarcinoma 7 70.92 Quite High
INFLAMMATION 22 69.40 Quite High
Mouth Cancer 4 69.28 Quite High
Breast Cancer 11 61.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurements were performed in duplicate and experiments were repeated two times. b Radiation-induced changes in KGF receptor expression in keratinocytes (KTC) and HaCat cells.
Regulation (changes) of Gene_expression (expression) of KGF receptor in keratinocytes
1) Confidence 0.62 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.29 Pain Relevance 0
Analysis of radiation-induced changes in KGF expression showed mRNA up-regulation in fibroblasts and no systematic changes of the regulation in tumour cells.
Regulation (changes) of Gene_expression (expression) of KGF in fibroblasts associated with cancer
2) Confidence 0.54 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.53 Pain Relevance 0
However, where tested, KGF expression was confirmed on the RNA level, suggesting true KGF synthesis in epithelial cells.
Regulation (confirmed) of Gene_expression (expression) of KGF in epithelial cells
3) Confidence 0.45 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.74 Pain Relevance 0.06
Figure 2a summarizes the results; the mRNA expression is normalized to the unirradiated controls.Fig. 2a Radiation-induced changes in KGF expression in normal (KTC = primary keratinocytes, HaCat = immortalized keratinocytes, DF-19 = primary fibroblasts) and tumour cells (BW-225, ZMK-1, GR-145, OH-65).
Regulation (changes) of Gene_expression (expression) of KGF in keratinocytes associated with cancer
4) Confidence 0.45 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
Closed bars represent cells plated in KGF-free medium; dashed bars represent cells plated in medium containing 0.2 ?
Regulation (plated) of Gene_expression (medium) of KGF-free in bars
5) Confidence 0.39 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.22 Pain Relevance 0
Closed bars represent cells plated in KGF-free medium; dashed bars represent cells plated in medium containing 0.2 ?
Regulation (plated) of Gene_expression (medium) of KGF-free in bars
6) Confidence 0.39 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.29 Pain Relevance 0
Closed bars represent cells plated in KGF-free medium; dashed bars represent cells plated in medium containing 0.2 ?
Regulation (plated) of Gene_expression (medium) of KGF-free in bars
7) Confidence 0.39 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.29 Pain Relevance 0
The down-regulation of KGF-1 expression in oral fibroblast cell lines potentially impairs the proliferation of overlying keratinocytes, which could partially explain the frequent epithelial atrophy observed in chronic areca chewers in vivo.
Regulation (regulation) of Gene_expression (expression) of KGF-1 in fibroblast associated with frailty
8) Confidence 0.05 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697755 Disease Relevance 0.31 Pain Relevance 0
The results showed up-regulation of IL-6 expression and down-regulation of PDGFR, APP-1 and KGF-1 expressions in multiple cell lines assayed.
Regulation (regulation) of Gene_expression (expressions) of KGF-1
9) Confidence 0.04 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697755 Disease Relevance 0.29 Pain Relevance 0

General Comments

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