INT200107

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.29
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHA) mitochondrion (SDHA) small molecule metabolic process (SDHA)
Anatomy Link Frequency
ligament 2
embryo 1
connective tissues 1
upper 1
SDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 109 97.72 Very High Very High Very High
imagery 1 73.52 Quite High
vagus nerve 2 37.96 Quite Low
Pain 15 35.44 Quite Low
Inflammation 4 34.08 Quite Low
cva 2 30.80 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 5 99.84 Very High Very High Very High
Cancer 105 98.14 Very High Very High Very High
Osteoarthritis 122 97.72 Very High Very High Very High
Malignant Neoplastic Disease 22 94.80 High High
Lymphadenopathy 5 92.20 High High
Choriocarcinoma 38 92.16 High High
Erythema 1 90.24 High High
Teratoma 6 89.76 High High
Pressure And Volume Under Development 1 89.72 High High
Seminoma 32 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When both sample groups were analysed together, the expression stability was reduced (M value = 0.57, Table 3), with SDHA and RPL13A identified as the most consistently expressed reference genes.
Gene_expression (expressed) of SDHA
1) Confidence 0.37 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.70 Pain Relevance 0.25
The expression stability of the optimal reference genes for normal cranial cruciate ligament tissue (SDHA and YWHAZ, M value = 0.26) and diseased tissue (SDHA and HPRT, M value = 0.33) (see Table 4) were broadly similar.
Gene_expression (expression) of SDHA in ligament
2) Confidence 0.29 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.63 Pain Relevance 0.26
The expression stability of the optimal reference genes for normal cranial cruciate ligament tissue (SDHA and YWHAZ, M value = 0.26) and diseased tissue (SDHA and HPRT, M value = 0.33) (see Table 4) were broadly similar.
Gene_expression (expression) of SDHA in ligament
3) Confidence 0.29 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.63 Pain Relevance 0.26
The geNorm algorithm is employed to investigate the expression stability of 9 commonly used reference genes (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], beta-2-microglobulin [B2M] hydroxymethylbilane synthase [HMBS], hypoxanthine guanine phosphoribosyl transferase [HPRT], ribosomal protein L13a [RPL13A], succinate dehydrogenase flavoprotein subunit A [SDHA], TATA box binding protein [TBP] and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [YWHAZ]) [11] in normal and diseased canine connective tissues.
Gene_expression (expression) of SDHA in connective tissues
4) Confidence 0.29 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.67 Pain Relevance 0.22
In contrast, for curcumin and diacerein-treated samples, HPRT1, GAPDH and B2M provided the most stable expression levels with SDHA ranking the 6th and 5th positions, respectively.
Gene_expression (expression) of SDHA
5) Confidence 0.25 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1820791 Disease Relevance 0 Pain Relevance 0
Alpha- fetoprotein (a-FP) and carcinoembryonic antigen (CEA) levels were within normal limits, while lactate dehydrogenase (LDH) level was two-fold higher than the normal upper limit.
Gene_expression (levels) of a-FP in upper
6) Confidence 0.10 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1697810 Disease Relevance 0.35 Pain Relevance 0
The next stage is that of the fertilized ovum and the formation of the blastocele which gives rise to both the embryo and the placenta: the neoplastic counterpart is the embryonal cell carcinoma, which produces high levels of a-FP concentration.
Gene_expression (produces) of a-FP in embryo associated with carcinoma
7) Confidence 0.09 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1697810 Disease Relevance 1.33 Pain Relevance 0
Many of the false negative detections (FN) were due to our self-imposed strict requirements for as few as possible false positive detections (FP).
Spec (possible) Gene_expression (detections) of FP
8) Confidence 0.05 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0.27 Pain Relevance 0
Tumor marker analysis revealed that CA-125 was mildly elevated (65 U/ml), while CA 19-9, CA 15-3, a-FP and CEA levels were all within normal limits.
Gene_expression (levels) of a-FP associated with cancer
9) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2249603 Disease Relevance 0.71 Pain Relevance 0.04

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