INT200132

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ercc2) chromosome segregation (Ercc2) helicase activity (Ercc2)
extracellular matrix organization (Ercc2) DNA binding (Ercc2) cytoplasm (Ercc2)
Anatomy Link Frequency
neurons 1
Ercc2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 52.52 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hutchinson-gilford Progeria Syndrome 85 98.76 Very High Very High Very High
Death 36 96.76 Very High Very High Very High
Lifespan 41 96.00 Very High Very High Very High
Freckles 10 95.16 Very High Very High Very High
Osteoporosis 3 94.76 High High
Cancer 19 94.32 High High
Kyphosis 14 94.20 High High
Congenital Anomalies 17 94.04 High High
Retina Disease 7 92.16 High High
Sensorineural Hearing Loss 3 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A related yet distinct disorder is trichothiodystrophy (TTD) (affected genes: XPB, XPD, or TTDA).
Regulation (affected) of XPD
1) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 1.84 Pain Relevance 0
Similarly, Purkinje neurons were morphologically intact in all mutant and control XPD/XPA animals at postnatal day 15 (Figure 3B).
Regulation (control) of XPD in neurons
2) Confidence 0.34 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.09 Pain Relevance 0
In contrast, how alterations in any of five NER-associated proteins (XPB, XPD, XPG, CSA, and CSB) can cause progeria remains largely obscure.
Regulation (alterations) of XPD associated with hutchinson-gilford progeria syndrome
3) Confidence 0.23 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.64 Pain Relevance 0.05

General Comments

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