INT200135

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.47
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Ercc3) nucleus (Ercc3) helicase activity (Ercc3)
DNA binding (Ercc3)
Ercc3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 52.52 Quite High
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hutchinson-gilford Progeria Syndrome 44 98.56 Very High Very High Very High
Death 23 96.76 Very High Very High Very High
Lifespan 27 96.00 Very High Very High Very High
Freckles 5 95.16 Very High Very High Very High
Osteoporosis 2 94.76 High High
Cancer 10 94.32 High High
Kyphosis 10 94.20 High High
Retina Disease 7 92.16 High High
Sensorineural Hearing Loss 2 91.28 High High
Gait Ataxia 1 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A related yet distinct disorder is trichothiodystrophy (TTD) (affected genes: XPB, XPD, or TTDA).
Regulation (affected) of XPB
1) Confidence 0.34 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 1.83 Pain Relevance 0
In contrast, how alterations in any of five NER-associated proteins (XPB, XPD, XPG, CSA, and CSB) can cause progeria remains largely obscure.
Regulation (alterations) of XPB associated with hutchinson-gilford progeria syndrome
2) Confidence 0.12 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.64 Pain Relevance 0.05

General Comments

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